The extracellular matrix (ECM) plays a key role as both structural scaffold and regulator of
cell signal transduction in tissues. In times of ECM assembly and turnover, cells upregulate …

Sensing the mechanical properties of the substrates or the matrix by the cells and the
tissues, the subsequent downstream responses at the cellular, nuclear and epigenetic levels …

The immunological synapse is a molecular hub that facilitates the delivery of three activation
signals, namely antigen, costimulation/corepression and cytokines, from antigen-presenting …

Abstract Heart-on-a-chip (HoC) has emerged as a highly efficient, cost-effective device for
the development of engineered cardiac tissue, facilitating high-throughput testing in drug …

Mechanical forces are known to be important in mammalian blastocyst formation; however,
due to limited tools, specific force inputs and how they relay to first cell fate control of inner …

Abstract Four-dimensional (4 D) printing is a novel emerging technology, which can be
defined as the ability of 3 D printed materials to change their form and functions. The term …

Quantifying small, rapidly evolving forces generated by cells is a major challenge for the
understanding of biomechanics and mechanobiology in health and disease. Traction force …

Clathrin-mediated endocytosis (CME) is the main mechanism by which mammalian cells
control their cell surface proteome. Proper operation of the pivotal CME cargo adaptor AP2 …

Mechanical force has repeatedly been highlighted to be involved in T cell activation.
However, the biological significance of mechanical force for T cell receptor signaling …

Quantifying mechanical forces generated by cellular systems has led to key insights into a
broad range of biological phenomena from cell adhesion to immune cell activation. Traction …