Nicotine is of importance as the addictive chemical in tobacco, pharmacotherapy for
smoking cessation, a potential medication for several diseases, and a useful probe drug for …

Rationale This review provides insight for the judicious selection of nicotine dose ranges
and routes of administration for in vivo studies. The literature is replete with reports in which …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

The food-borne trematodiases are an important group of neglected tropical diseases
(NTDs). Over 40 million people are infected with food-borne trematodes and 750 million (> …

Background: Infection with liver flukes has been reported to be associated with bile duct
malignancy. Methods: The review is based on a literature search (Medline) and, in some …

Understanding the relationships between human genetic factors, the risks of develo**
major diseases and the molecular basis of drug efficacy and toxicity is a fundamental …

Much of P450 research has always been done with the view of appUcation to humans, even
when done with experimental animals and microorganisms. Research with the human …

Background: Available in-vitro and animal studies indicate that inflammation impacts
cytochromes P450 (CYP) activity via multiple and complex transcriptional and post …

Cholangiocarcinoma has a worldwide distribution which accounts for about 10–15% of all
cases of primary hepatobiliary malignancy. Although, in the majority of cases, no aetiological …

Coumarin 7-hydroxylation is catalysed by a high-affinity CYP2A6 enzyme in human liver
microsomes. CYP2A6 is the only enzyme catalysing this reaction and consequently the …