Cellular functions of eukaryotic RNA helicases and their links to human diseases
RNA helicases are highly conserved proteins that use nucleoside triphosphates to bind or
remodel RNA, RNA–protein complexes or both. RNA helicases are classified into the DEAD …
remodel RNA, RNA–protein complexes or both. RNA helicases are classified into the DEAD …
Natural compounds modulating mitophagy: Implications for cancer therapy
M Cao, Y Tang, Y Luo, F Gu, Y Zhu, X Liu, C Yan, W Hu… - Cancer Letters, 2024 - Elsevier
Cancer is considered as the second leading cause of mortality, and cancer incidence is still
growing rapidly worldwide, which poses an increasing global health burden. Although …
growing rapidly worldwide, which poses an increasing global health burden. Although …
Targeting EIF4A triggers an interferon response to synergize with chemotherapy and suppress triple-negative breast cancer
Protein synthesis is frequently dysregulated in cancer and selective inhibition of mRNA
translation represents an attractive cancer therapy. Here, we show that therapeutically …
translation represents an attractive cancer therapy. Here, we show that therapeutically …
Calibrated ribosome profiling assesses the dynamics of ribosomal flux on transcripts
Ribosome profiling, which is based on deep sequencing of ribosome footprints, has served
as a powerful tool for elucidating the regulatory mechanism of protein synthesis. However …
as a powerful tool for elucidating the regulatory mechanism of protein synthesis. However …
Targeted Covalent Modification Strategies for Drugging the Undruggable Targets
The term “undruggable” refers to proteins or other biological targets that have been
historically challenging to target with conventional drugs or therapeutic strategies because …
historically challenging to target with conventional drugs or therapeutic strategies because …
The human DEAD-box helicase DDX3X as a regulator of mRNA translation
CS Ryan, M Schröder - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
The human DEAD-box protein DDX3X is an RNA remodelling enzyme that has been
implicated in various aspects of RNA metabolism. In addition, like many DEAD-box proteins …
implicated in various aspects of RNA metabolism. In addition, like many DEAD-box proteins …
DMDA-PatA mediates RNA sequence-selective translation repression by anchoring eIF4A and DDX3 to GNG motifs
H Saito, Y Handa, M Chen… - Nature …, 2024 - nature.com
Small-molecule compounds that elicit mRNA-selective translation repression have attracted
interest due to their potential for expansion of druggable space. However, only a limited …
interest due to their potential for expansion of druggable space. However, only a limited …
Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as a therapeutic strategy in CLL
Dysregulation of messenger RNA (mRNA) translation, including preferential translation of
mRNA with complex 5′ untranslated regions such as the MYC oncogene, is recognized as …
mRNA with complex 5′ untranslated regions such as the MYC oncogene, is recognized as …
A second-generation eIF4A RNA helicase inhibitor exploits translational reprogramming as a vulnerability in triple-negative breast cancer
In this study, we aimed to address the current limitations of therapies for macro-metastatic
triple-negative breast cancer (TNBC) and provide a therapeutic lead that overcomes the …
triple-negative breast cancer (TNBC) and provide a therapeutic lead that overcomes the …
Ribosome profiling: a powerful tool in oncological research
D Su, C Ding, J Qiu, G Yang, R Wang, Y Liu, J Tao… - Biomarker …, 2024 - Springer
Neoplastic cells need to adapt their gene expression pattern to survive in an ever-changing
or unfavorable tumor microenvironment. Protein synthesis (or mRNA translation), an …
or unfavorable tumor microenvironment. Protein synthesis (or mRNA translation), an …