Scar formation resulting from burns or severe trauma can significantly compromise the
structural integrity of skin and lead to permanent loss of skin appendages, ultimately …

Mechanical forces impact cardiac cells and tissues over their entire lifespan, from
development to growth and eventually to pathophysiology. However, the mechanobiological …

Organoid Intelligence ushers in a new era by seamlessly integrating cutting-edge organoid
technology with the power of artificial intelligence. Organoids, three-dimensional miniature …

Surface wrinkling provides an approach to modify the surfaces of biomedical devices to
better mimic features of the extracellular matrix and guide cell attachment, proliferation, and …

The mechanical function of the myocardium is defined by cardiomyocyte contractility and the
biomechanics of the extracellular matrix (ECM). Understanding this relationship remains an …

Mechanical stimulation is an effective approach for controlling stem cell differentiation in
tissue engineering. However, its realization in in vivo tissue repair remains challenging …

Mechanotransduction refers to the ability of cells to sense mechanical stimuli and convert
them into biochemical signals. In this context, the key players are focal adhesions (FAs) …

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) are a promising cell
source for cardiac regenerative medicine and in vitro modeling. However, hPSC-CMs exhibit …

Cell culture substrates designed for myocardial applications are pivotal in promoting the
maturation and functional integration of cardiomyocytes. However, traditional in vitro models …

Stem cells have been one of the ideal sources for tissue regeneration owing to their
capability of self-renewal and differentiation. In vivo, the extracellular microenvironment …