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[HTML][HTML] Feedback regulation of RTK signaling in development
Precise regulation of the amplitude and duration of receptor tyrosine kinase (RTK) signaling
is critical for the execution of cellular programs and behaviors. Understanding these control …
is critical for the execution of cellular programs and behaviors. Understanding these control …
Racial and ethnic disparities in early treatment with immunotherapy for advanced HCC in the United States
Conclusions Immunotherapy was associated with improved OS compared with
chemotherapy in advanced HCC. There are significant disparities in early access to …
chemotherapy in advanced HCC. There are significant disparities in early access to …
Skeletal muscle SIRT3 deficiency contributes to pulmonary vascular remodeling in pulmonary hypertension due to heart failure with preserved ejection fraction
BACKGROUND: Pulmonary hypertension (PH) is a major complication linked to adverse
outcomes in heart failure with preserved ejection fraction (HFpEF), yet no specific therapies …
outcomes in heart failure with preserved ejection fraction (HFpEF), yet no specific therapies …
Progress in research on CNPY2 in diseases
K Chen, Y Zhang, Z Wang… - Mini Reviews in Medicinal …, 2024 - benthamdirect.com
Canopy FGF signaling regulator 2 (CNPY2) is a novel angiogenic growth factor. In recent
years, increasing evidence highlights that CNPY2 has important functions in health and …
years, increasing evidence highlights that CNPY2 has important functions in health and …
VEGF-loaded microsphere patch for local protein delivery to the ischemic heart
Background: Revascularization of the heart after myocardial infarction (MI) using growth
factors delivered by hydrogel-based microspheres represents a promising therapeutic …
factors delivered by hydrogel-based microspheres represents a promising therapeutic …
CNPY2 protects against ER stress and is expressed by corticostriatal neurons together with CTIP2 in a mouse model of Huntington's disease
M Scordino, P Stepanova, V Srinivasan… - Frontiers in Molecular …, 2024 - frontiersin.org
Canopy Homolog 2 (CNPY2) is an endoplasmic reticulum (ER) localized protein belonging
to the CNPY gene family. We show here that CNPY2 is protective against ER stress induced …
to the CNPY gene family. We show here that CNPY2 is protective against ER stress induced …
TWEAK protects cardiomyocyte against apoptosis in a PI3K/AKT pathway dependent manner
B Yang, P Yan, H Gong, L Zuo, Y Shi… - American Journal of …, 2016 - pmc.ncbi.nlm.nih.gov
Myocyte apoptosis is a key determinant of cardiac recovery and prognosis of patients with
acute myocardial infarction (AMI). Tumor necrosis factor (TNF)-like weak inducer of …
acute myocardial infarction (AMI). Tumor necrosis factor (TNF)-like weak inducer of …
Slee** Beauty insertional mutagenesis screen identifies the pro-metastatic roles of CNPY2 and ACTN2 in hepatocellular carcinoma tumor progression
LH Lo, CY Lam, JC To, CH Chiu, VW Keng - Biochemical and biophysical …, 2021 - Elsevier
A forward genetic Slee** Beauty (SB) insertional mutagenesis screen, followed by high-
throughput transcriptome sequencing, was used to identify driver genes responsible for …
throughput transcriptome sequencing, was used to identify driver genes responsible for …
Identification of NCK1 as a novel downstream effector of STAT3 in colorectal cancer metastasis and angiogenesis
F Zhang, Y Lu, Q Chen, H Zou, J Zhang, Y Hu, X Li… - Cellular signalling, 2017 - Elsevier
Signal transducer and activator of transcription 3 (STAT3) is known to activate targets
associated with invasion, proliferation, and angiogenesis in a wide variety of cancers. The …
associated with invasion, proliferation, and angiogenesis in a wide variety of cancers. The …
miR-30a-3p suppresses the proliferation and migration of lung adenocarcinoma cells by downregulating CNPY2
H Wang, D Kanmangne, R Li, Z Qian… - Oncology …, 2020 - spandidos-publications.com
Lung cancer is a leading cause of cancer-related morbidity and mortality worldwide.
Although there are currently various therapeutic strategies including surgery, chemotherapy …
Although there are currently various therapeutic strategies including surgery, chemotherapy …