Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental
cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with …

Wnt/β-catenin signaling is an evolutionarily conserved and versatile pathway that is known
to be involved in embryonic development, tissue homeostasis and a wide variety of human …

Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor for
gastric cancer. The cagA gene product, CagA, is delivered into gastric epithelial cells via the …

RUNX proteins belong to a family of metazoan transcription factors that serve as master
regulators of development. They are frequently deregulated in human cancers, indicating a …

Gastric cancer remains one of the most common cancers worldwide and one of the leading
cause for cancer-related deaths. Gastric adenocarcinoma is a multifactorial disease that is …

Streptococcus gallolyticus subsp. gallolyticus (Sg) has long been known to have a strong
association with colorectal cancer (CRC). This knowledge has important clinical …

Abstract The Polycomb group (PcG) proteins are transcriptional repressors that regulate
lineage choices during development and differentiation. Recent studies have advanced our …

Rationale: Cancer stem cells (CSCs) are considered to be essential for tumorigenesis,
recurrence, and metastasis and therefore serve as a biomarker for tumor progression in …

Histone modifications are thought to control the regulation of genetic programs in normal
physiology and cancer. Methylation (mono-, di-, and tri-methylation) on histone H3 lysine (K) …