Bacteriophage T4 nanoparticles for vaccine delivery against infectious diseases
Subunit vaccines containing one or more target antigens from pathogenic organisms
represent safer alternatives to whole pathogen vaccines. However, the antigens by …
represent safer alternatives to whole pathogen vaccines. However, the antigens by …
Inorganic and polymeric nanoparticles for human viral and bacterial infections prevention and treatment
JJ Aguilera-Correa, J Esteban, M Vallet-Regí - Nanomaterials, 2021 - mdpi.com
Infectious diseases hold third place in the top 10 causes of death worldwide and were
responsible for more than 6.7 million deaths in 2016. Nanomedicine is a multidisciplinary …
responsible for more than 6.7 million deaths in 2016. Nanomedicine is a multidisciplinary …
Engineering of bacteriophage T4 genome using CRISPR-Cas9
Bacteriophages likely constitute the largest biomass on Earth. However, very few phage
genomes have been well-characterized, the tailed phage T4 genome being one of them …
genomes have been well-characterized, the tailed phage T4 genome being one of them …
A bacteriophage T4 nanoparticle-based dual vaccine against anthrax and plague
Bacillus anthracis and Yersinia pestis, the causative agents of anthrax and plague,
respectively, are two of the deadliest pathogenic bacteria that have been used as biological …
respectively, are two of the deadliest pathogenic bacteria that have been used as biological …
Cryo-EM structure of the bacteriophage T4 isometric head at 3.3-Å resolution and its relevance to the assembly of icosahedral viruses
The 3.3-Å cryo-EM structure of the 860-Å-diameter isometric mutant bacteriophage T4
capsid has been determined. WT T4 has a prolate capsid characterized by triangulation …
capsid has been determined. WT T4 has a prolate capsid characterized by triangulation …
T4 bacteriophage nanoparticles engineered through CRISPR provide a versatile platform for rapid development of flu mucosal vaccines
M Li, C Chen, X Wang, P Guo, H Feng, X Zhang… - Antiviral Research, 2023 - Elsevier
Vaccines that trigger mucosal immune responses at the entry portals of pathogens are
highly desired. Here, we showed that antigen-decorated nanoparticle generated through …
highly desired. Here, we showed that antigen-decorated nanoparticle generated through …
Unexpected evolutionary benefit to phages imparted by bacterial CRISPR-Cas9
Bacteria and bacteriophages arm themselves with various defensive and counterdefensive
mechanisms to protect their own genome and degrade the other's. CRISPR (clustered …
mechanisms to protect their own genome and degrade the other's. CRISPR (clustered …
Engineering T4 Bacteriophage for In Vivo Display by Type V CRISPR-Cas Genome Editing
Bacteriophage T4 has enormous potential for biomedical applications due to its large size,
capsid architecture, and high payload capability for protein and DNA delivery. However, it is …
capsid architecture, and high payload capability for protein and DNA delivery. However, it is …
Specific integration of temperate phage decreases the pathogenicity of host bacteria
Y Chen, L Yang, D Yang, J Song, C Wang… - Frontiers in Cellular …, 2020 - frontiersin.org
Temperate phages are considered as natural vectors for gene transmission among bacteria
due to the ability to integrate their genomes into a host chromosome, therefore, affect the …
due to the ability to integrate their genomes into a host chromosome, therefore, affect the …
Bacteriophage T4 vaccine platform for next-generation influenza vaccine development
M Li, P Guo, C Chen, H Feng, W Zhang, C Gu… - Frontiers in …, 2021 - frontiersin.org
Develo** influenza vaccines that protect against a broad range of viruses is a global
health priority. Several conserved viral proteins or domains have been identified as …
health priority. Several conserved viral proteins or domains have been identified as …