T cell responses in patients with COVID-19
Z Chen, E John Wherry - Nature Reviews Immunology, 2020 - nature.com
The role of T cells in the resolution or exacerbation of COVID-19, as well as their potential to
provide long-term protection from reinfection with SARS-CoV-2, remains debated …
provide long-term protection from reinfection with SARS-CoV-2, remains debated …
SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes
J Nikolich-Zugich, KS Knox, CT Rios, B Natt… - Geroscience, 2020 - Springer
Abstract SARS-CoV-2 virus, the causative agent of the coronavirus infectious disease-19
(COVID-19), is taking the globe by storm, approaching 500,000 confirmed cases and over …
(COVID-19), is taking the globe by storm, approaching 500,000 confirmed cases and over …
[HTML][HTML] Health consequences of thymus removal in adults
Background The function of the thymus in human adults is unclear, and routine removal of
the thymus is performed in a variety of surgical procedures. We hypothesized that the adult …
the thymus is performed in a variety of surgical procedures. We hypothesized that the adult …
Local and systemic responses to SARS-CoV-2 infection in children and adults
M Yoshida, KB Worlock, N Huang, RGH Lindeboom… - Nature, 2022 - nature.com
It is not fully understood why COVID-19 is typically milder in children,–. Here, to examine the
differences between children and adults in their response to SARS-CoV-2 infection, we …
differences between children and adults in their response to SARS-CoV-2 infection, we …
[HTML][HTML] Molecular mimicry and autoimmunity
Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents
may induce autoimmunity. It occurs when similarities between foreign and self-peptides …
may induce autoimmunity. It occurs when similarities between foreign and self-peptides …
Reversal of epigenetic aging and immunosenescent trends in humans
GM Fahy, RT Brooke, JP Watson, Z Good… - Aging cell, 2019 - Wiley Online Library
Epigenetic “clocks” can now surpass chronological age in accuracy for estimating biological
age. Here, we use four such age estimators to show that epigenetic aging can be reversed …
age. Here, we use four such age estimators to show that epigenetic aging can be reversed …
Guidelines for the use of flow cytometry and cell sorting in immunological studies
A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2019 - Wiley Online Library
These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …
immunology and flow cytometry community. They provide the theory and key practical …
Mechanisms underlying T cell ageing
JJ Goronzy, CM Weyand - Nature Reviews Immunology, 2019 - nature.com
T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and
cancer and in impairing the response to vaccination. Easy accessibility to peripheral human …
cancer and in impairing the response to vaccination. Easy accessibility to peripheral human …
T cell receptor‐based cancer immunotherapy: emerging efficacy and pathways of resistance
SS Chandran, CA Klebanoff - Immunological reviews, 2019 - Wiley Online Library
Adoptive cell transfer (ACT) using chimeric antigen receptor (CAR)‐modified T cells can
induce durable remissions in patients with refractory B‐lymphoid cancers. By contrast …
induce durable remissions in patients with refractory B‐lymphoid cancers. By contrast …
Age‐related thymic involution: Mechanisms and functional impact
The thymus is the primary immune organ responsible for generating self‐tolerant and
immunocompetent T cells. However, the thymus gradually involutes during early life …
immunocompetent T cells. However, the thymus gradually involutes during early life …