Small populations of adult stem cells are responsible for the remarkable ability of the
epithelial lining of the intestine to be efficiently renewed and repaired throughout life. The …

Due to its intense self-renewal kinetics and its simple repetitive architecture, the intestinal
epithelium has become a prime model for studying adult stem cells in health and disease …

Intestinal stem cells, characterized by high Lgr5 expression, reside between Paneth cells at
the small intestinal crypt base and divide every day. We have carried out fate map** of …

Two types of stem cells are currently defined in small intestinal crypts: cycling crypt base
columnar (CBC) cells and quiescent '+ 4'cells. Here, we combine transcriptomics with …

The small intestine epithelium undergoes rapid and continuous regeneration supported by
crypt intestinal stem cells (ISCs). Bmi1 and Lgr5 have been independently identified to mark …

Intestinal epithelial stem cell identity and location have been the subject of substantial
research. Cells in the+ 4 niche are slow-cycling and label-retaining, whereas a different …

The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. It is
currently believed that four to six crypt stem cells reside at the+ 4 position immediately above …

Signaling initiated by secreted glycoproteins of the Wnt family regulates many aspects of
embryonic development and it is involved in homeostasis of adult tissues. In the …

The lining of the intestine is renewed at an extraordinary rate, outpacing all other tissues in
the vertebrate body. The renewal process is neatly organized in space, so that the whole …

The Wnt signaling pathway is deregulated in over 90% of human colorectal cancers. β-
Catenin, the central signal transducer of the Wnt pathway, can directly modulate gene …