The global scale-up of antiretroviral (ARV) therapy (ART) has led to dramatic reductions in
HIV-1 mortality and incidence. However, HIV drug resistance (HIVDR) poses a potential …

Background The presence of high-abundance drug-resistant HIV-1 jeopardizes success of
antiretroviral therapy (ART). Despite numerous investigations, the clinical impact of low …

Background Contemporary antiretroviral therapies (ART) and management strategies have
diminished both human immunodeficiency virus (HIV) treatment failure and the acquired …

Background WHO has developed a global HIV-drug resistance surveillance strategy,
including assessment of pretreatment HIV-drug resistance. We aimed to do a nationally …

The ability of next-generation sequencing (NGS) technologies to detect low frequency HIV-1
drug resistance mutations (DRMs) not detected by dideoxynucleotide Sanger sequencing …

Next generation sequencing (NGS) is a trending new standard for genotypic HIV-1 drug
resistance (HIVDR) testing. Many NGS HIVDR data analysis pipelines have been …

Background Implementation of ultrasensitive HIV drug resistance tests for routine clinical
use is hampered by uncertainty about the clinical relevance of drug-resistant minority …

Human immunodeficiency virus type 1 (HIV-1) drug resistance genoty** is recommended
to help in the selection of antiretroviral therapy and to prevent virologic failure. There are …

The emerging HIV-1 resistance epidemic is threatening the impressive global advances in
HIV-1 infection treatment and prevention achieved in the last decade. Next-generation …

High-quality, simplified, and low-cost human immunodeficiency virus (HIV) drug resistance
tests that are able to provide timely actionable HIV resistance data at individual, population …