Tuberculosis (TB) is the leading infectious cause of mortality worldwide, due in part to a
limited understanding of its clinical pathogenic spectrum of infection and disease …

Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

Dendritic cells (DC) are specialized immune cells that play a critical role in promoting an
immune response against Ags, which can include foreign pathogenic Ags and self-tumor …

There are 9 million cases of active tuberculosis reported annually; however, an estimated
one-third of the world's population is infected with Mycobacterium tuberculosis and remains …

Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the
leading cause of death from an infectious disease, with a mortality rate of over a million …

The resurgence of tuberculosis worldwide has intensified research efforts directed at
examining the host defense and pathogenic mechanisms operative in Mycobacterium …

Almost all of the key molecules involved in the innate and adaptive immune response are
glycoproteins. In the cellular immune system, specific glycoforms are involved in the folding …

Control of infection with Mycobacterium tuberculosis (Mtb) requires Th1-type immunity, of
which CD8+ T cells play a unique role. High frequency Mtb-reactive CD8+ T cells are …

Inflammation initiates clotting, decreases the activity of natural anticoagulant mechanisms
and impairs the fibrinolytic system. Inflammatory cytokines are the major mediators involved …

The different manifestations of infection with Mycobacterium tuberculosis reflect the balance
between the bacillus and host defense mechanisms. Traditionally, protective immunity to …