Protein kinase C (PKC) isoforms comprise a family of lipid-activated enzymes that have
been implicated in a wide range of cellular functions. PKCs are modular enzymes comprised …

Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …

Protein kinase C (PKC), a family of related serine‐threonine kinases, is a key player in the
cellular responses mediated by the second messenger diacylglycerol (DAG) and the …

Latrunculin A is used extensively as an agent to sequester monomeric actin in living cells.
We hypothesize that additional activities of latrunculin A may be important for its biological …

Understanding the molecular interactions among components of cardiac Z-discs and their
role in signaling has become pivotal in explaining long-and short-term regulation of cardiac …

Members of the protein kinase C family respond to second messengers and are involved in
controlling a broad array of cellular functions. The overlap** specificity and promiscuity of …

Myofibroblasts are ultrastructurally and metabolically distinctive fibroblasts that express
smooth muscle (SM)-α actin and are associated with various fibrotic lesions. The present …

Abstract The binding of Ab (IgG)-opsonized particles by FcγRs on macrophages results in
phagocytosis of the particles and generation of a respiratory burst. Both IgG-stimulated …

Members of the protein kinase C (PKC) family have long been studied for their contributions
to oncogenesis. Among the ten different isoforms of this family of serine/threonine kinases …

Tumor metastasis is the major cause of morbidity and mortality in patients with breast
cancer. It is critical to identify metastasis enabling genes and understand how they are …