The existence of free radicals in living cells was first reported in 1954 and this important
finding helped launch the field of free radical biology. However, the discovery that muscular …

The first suggestion that physical exercise results in free radical-mediated damage to tissues
appeared in 1978, and the past three decades have resulted in a large growth of knowledge …

The plasticity of skeletal muscle can be traced down to extensive metabolic, structural and
molecular remodeling at the single fiber level. Skeletal muscle is comprised of different fiber …

It is well established that contracting muscles produce both reactive oxygen and nitrogen
species. Although the sources of oxidant production during exercise continue to be debated …

The observation that muscular exercise is associated with oxidative stress in humans was
first reported over 30years ago. Since this initial report, numerous studies have confirmed …

This review offers an overview of the influence of reactive species produced during exercise
and their effect on exercise adaptation. Reactive species and free radicals are unstable …

Increased reactive oxygen species (ROS) production is crucial to the remodelling that occurs
in skeletal muscle in response to both exercise training and prolonged periods of disuse …

It is well established that contracting skeletal muscles produce free radicals. Given that
radicals are known to play a prominent role in the pathogenesis of several diseases, the …

Context: Overproduction of reactive oxygen and nitrogen species during physical exercise,
exercise induced oxidative stress and antioxidant supplementation is interesting and …

Skeletal muscle adapts to the stress of contractile activity via changes in gene expression to
yield an increased content of a family of highly conserved cytoprotective proteins known as …