Cannabidiol and neurodegeneration: From molecular mechanisms to clinical benefits
Neurodegenerative disorders (NDs) such as Alzheimer's disease, Parkinson's disease,
Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis are severe and …
Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis are severe and …
Emerging therapeutic potential of cannabidiol (CBD) in neurological disorders: a comprehensive review
Cannabidiol (CBD), derived from Cannabis sativa, has gained remarkable attention for its
potential therapeutic applications. This thorough analysis explores the increasing …
potential therapeutic applications. This thorough analysis explores the increasing …
Cannabidiol ameliorates mitochondrial disease via PPARγ activation in preclinical models
E Puighermanal, M Luna-Sánchez, A Gella… - Nature …, 2024 - nature.com
Mutations in mitochondrial energy-producing genes lead to a heterogeneous group of
untreatable disorders known as primary mitochondrial diseases (MD). Leigh syndrome (LS) …
untreatable disorders known as primary mitochondrial diseases (MD). Leigh syndrome (LS) …
Determining antioxidant activity of Cannabis leaves extracts from different varieties—Unveiling nature's treasure trove
Cannabis leaves contain a diverse range of antioxidants, including cannabinoids,
flavonoids, and phenolic compounds, which offer significant health benefits. Utilising …
flavonoids, and phenolic compounds, which offer significant health benefits. Utilising …
Cannabidiol acts as molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediators
LK Peltner, L Gluthmann, F Börner, S Pace… - Cell Chemical …, 2023 - cell.com
Cannabinoids are phytochemicals from cannabis with anti-inflammatory actions in immune
cells. Lipid mediators (LM), produced from polyunsaturated fatty acids (PUFA), are potent …
cells. Lipid mediators (LM), produced from polyunsaturated fatty acids (PUFA), are potent …
Cannabinoids in the modulation of oxidative signaling
Cannabis sativa-derived compounds, such as delta-9-tetrahydrocannabinol (THC) and
cannabidiol (CBD), and components of the endocannabinoids system, such as N …
cannabidiol (CBD), and components of the endocannabinoids system, such as N …
Investigation of Cannabis sativa Phytochemicals as Anti-Alzheimer's Agents: An In Silico Study
Cannabis sativa is a medicinal plant that has been known for years and is used as an
Ayurvedic medicine. This plant has great potential in treating various types of brain …
Ayurvedic medicine. This plant has great potential in treating various types of brain …
Parkinson's disease, epilepsy, and amyotrophic lateral sclerosis—emerging role of AMPA and kainate subtypes of ionotropic glutamate receptors
MN Vukolova, LY Yen, MI Khmyz… - Frontiers in Cell and …, 2023 - frontiersin.org
Ionotropic glutamate receptors (iGluRs) mediate the majority of excitatory neurotransmission
and are implicated in various neurological disorders. In this review, we discuss the role of …
and are implicated in various neurological disorders. In this review, we discuss the role of …
Plant-derived compounds and neurodegenerative diseases: Different mechanisms of action with therapeutic potential
C Echeverry, M Pazos, M Torres-Pérez, G Prunell - Neuroscience, 2024 - Elsevier
Neurodegenerative diseases are a group of disorders characterized by progressive
degeneration of discrete groups of neurons causing severe disability. The main risk factor is …
degeneration of discrete groups of neurons causing severe disability. The main risk factor is …
[HTML][HTML] FDA-approved cannabidiol [Epidiolex®] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and …
Chronic Gulf War Illness (GWI) is characterized by cognitive and mood impairments, as well
as persistent neuroinflammation and oxidative stress. This study aimed to investigate the …
as persistent neuroinflammation and oxidative stress. This study aimed to investigate the …