Prokaryotic adaptive immune systems use Clustered Regularly Interspaced Short
Palindromic Repeats (CRISPRs) and CRISPR-associated (Cas) proteins for RNA-guided …

Highlights•Different antiphage systems are encoded in one bacterial genome.•Bacterial
antiphage systems can function in synergy through different strategies.•Antiphage systems …

Bacterial class 2 CRISPR-Cas systems utilize a single RNA-guided protein effector to
mitigate viral infection. We aggregated genomic data from multiple sources and constructed …

Abstract Bacteriophage exclusion ('BREX') phage restriction systems are found in a wide
range of bacteria. Various BREX systems encode unique combinations of proteins that …

Bacteria use diverse immune systems to defend themselves from ubiquitous viruses termed
bacteriophages (phages). Many anti-phage systems function by abortive infection to kill a …

Bacteria are under constant assault by bacteriophages and other mobile genetic elements.
As a result, bacteria have evolved a multitude of systems that protect from attack. Genes …

The eukaryotic replisome is assembled around the CMG (CDC45-MCM-GINS) replicative
helicase, which encircles the leading-strand DNA template at replication forks. When CMG …

Transcriptional regulation plays a central role in adaptation to changing environments for all
living organisms. Recently, proteins belonging to a novel widespread class of bacterial …

The DNA damage response in mycobacteria is controlled by the heterodimeric transcription
factor PafBC, a member of the WYL domain–containing protein family. It has been shown …

DNA damage repair systems are critical for genomic integrity. However, they must be
coordinated with DNA replication and cell division to ensure accurate genomic transmission …