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Targeting cell cycle regulation in cancer therapy
Cell proliferation is an essential mechanism for growth, development and regeneration of
eukaryotic organisms; however, it is also the cause of one of the most devastating diseases …
eukaryotic organisms; however, it is also the cause of one of the most devastating diseases …
Oncogenic regulation of tumor metabolic reprogramming
Development of malignancy is accompanied by a complete metabolic reprogramming
closely related to the acquisition of most of cancer hallmarks. In fact, key oncogenic …
closely related to the acquisition of most of cancer hallmarks. In fact, key oncogenic …
General aspects of colorectal cancer
Colorectal cancer (CRC) is one of the main causes of death. Cancer is initiated by several
DNA damages, affecting proto‐oncogenes, tumour suppressor genes, and DNA repairing …
DNA damages, affecting proto‐oncogenes, tumour suppressor genes, and DNA repairing …
Modulation of pentose phosphate pathway during cell cycle progression in human colon adenocarcinoma cell line HT29
P Vizán, G Alcarraz‐Vizán… - … journal of cancer, 2009 - Wiley Online Library
Cell cycle regulation is dependent on multiple cellular and molecular events. Cell
proliferation requires metabolic sources for the duplication of DNA and cell size. However …
proliferation requires metabolic sources for the duplication of DNA and cell size. However …
Characterization of the metabolic changes underlying growth factor angiogenic activation: identification of new potential therapeutic targets
Angiogenesis is a fundamental process to normal and abnormal tissue growth and repair,
which consists of recruiting endothelial cells toward an angiogenic stimulus. The cells …
which consists of recruiting endothelial cells toward an angiogenic stimulus. The cells …
Transketolase is upregulated in metastatic peritoneal implants and promotes ovarian cancer cell proliferation
Ovarian cancer, the most lethal gynaecological cancer, is characterised by the shedding of
epithelial cells from the ovarian surface, followed by metastasis and implantation onto the …
epithelial cells from the ovarian surface, followed by metastasis and implantation onto the …
Pentose phosphate cycle oxidative and nonoxidative balance: a new vulnerable target for overcoming drug resistance in cancer
A Ramos‐Montoya, WNP Lee… - … journal of cancer, 2006 - Wiley Online Library
The metabolic network of cancer cells confers adaptive mechanisms against many
chemotherapeutic agents, but also presents critical constraints that make the cells …
chemotherapeutic agents, but also presents critical constraints that make the cells …
Estradiol stimulates the biosynthetic pathways of breast cancer cells: detection by metabolic flux analysis
Selective estrogen receptor (ER) modulators are highly successful breast cancer therapies,
but they are not effective in patients with ER negative and selective estrogen receptor …
but they are not effective in patients with ER negative and selective estrogen receptor …
Energy metabolism in H460 lung cancer cells: effects of histone deacetylase inhibitors
Background Tumor cells are characterized by accelerated growth usually accompanied by
up-regulated pathways that ultimately increase the rate of ATP production. These cells can …
up-regulated pathways that ultimately increase the rate of ATP production. These cells can …
Transketolase-like 1 expression is modulated during colorectal cancer progression and metastasis formation
Background Transketolase-like 1 (TKTL1) induces glucose degradation through anaerobic
pathways, even in presence of oxygen, favoring the malignant aerobic glycolytic phenotype …
pathways, even in presence of oxygen, favoring the malignant aerobic glycolytic phenotype …