European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender
Background Lynch syndrome is the most common genetic predisposition for hereditary
cancer but remains underdiagnosed. Large prospective observational studies have recently …
cancer but remains underdiagnosed. Large prospective observational studies have recently …
Endometrial cancer
Endometrial cancer is the most common gynaecological cancer in high income countries
and its incidence is rising globally. Although an ageing population and fewer benign …
and its incidence is rising globally. Although an ageing population and fewer benign …
[HTML][HTML] Delphi initiative for early-onset colorectal cancer (DIRECt) international management guidelines
Background & Aims Patients with early-onset colorectal cancer (eoCRC) are managed
according to guidelines that are not age-specific. A multidisciplinary international group …
according to guidelines that are not age-specific. A multidisciplinary international group …
British Gynaecological Cancer Society (BGCS) uterine cancer guidelines: Recommendations for practice
The remit of this guideline is to collate and propose evidence-based guidelines for the
diagnosis and management of uterine cancer. This document covers all uterine cancers of …
diagnosis and management of uterine cancer. This document covers all uterine cancers of …
[HTML][HTML] The proportion of endometrial cancers associated with Lynch syndrome: a systematic review of the literature and meta-analysis
NAJ Ryan, MA Glaire, D Blake, M Cabrera-Dandy… - Genetics in …, 2019 - Elsevier
Purpose Endometrial cancer (EC) is often the sentinel cancer in women with Lynch
syndrome (LS). However, efforts to implement universal LS screening in EC patients have …
syndrome (LS). However, efforts to implement universal LS screening in EC patients have …
Molecular pathology of Lynch syndrome
Lynch syndrome (LS) is characterised by predisposition to colorectal, endometrial, and other
cancers and is caused by inherited pathogenic variants affecting the DNA mismatch repair …
cancers and is caused by inherited pathogenic variants affecting the DNA mismatch repair …
Endometrial cancer in Lynch syndrome
S Zhao, L Chen, Y Zang, W Liu, S Liu… - … Journal of Cancer, 2022 - Wiley Online Library
Lynch syndrome (LS) is an autosomal dominant inherited disease caused by germline
pathogenic variants (PVs) in mismatch repair (MMR) genes. LS‐associated endometrial …
pathogenic variants (PVs) in mismatch repair (MMR) genes. LS‐associated endometrial …
Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treatment: a report …
Summary Background The Prospective Lynch Syndrome Database (PLSD) collates
information on carriers of pathogenic or likely pathogenic MMR variants (path_MMR) who …
information on carriers of pathogenic or likely pathogenic MMR variants (path_MMR) who …
[HTML][HTML] Lynch syndrome genetics and clinical implications
Lynch syndrome (LS) is one of the most prevalent hereditary cancer syndromes in humans
and accounts for some 3% of unselected patients with colorectal or endometrial cancer and …
and accounts for some 3% of unselected patients with colorectal or endometrial cancer and …
Hereditary ovarian cancer: towards a cost-effective prevention strategy
A Ghose, A Bolina, I Mahajan, SA Raza… - International Journal of …, 2022 - mdpi.com
Ovarian cancer (OC) is the most lethal gynaecological malignancy. The search for a widely
affordable and accessible screening strategy to reduce mortality from OC is still ongoing …
affordable and accessible screening strategy to reduce mortality from OC is still ongoing …