Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

JARID1 proteins are histone demethylases that both regulate normal cell fates during
development and contribute to the epigenetic plasticity that underlies malignant …

Congenital heart disease (CHD) survivors are at risk for neurodevelopmental disability
(NDD), and recent studies identify genes associated with both disorders, suggesting that …

Histone methylation is one of the most important chromatin posttranslational modifications. It
has a range of influences on nuclear functions including epigenetic inheritance …

Histone demethylases are known to play important roles in the determination of the fate of
stem cells and in cancer progression. In this study, we show that the lysine 4 of histone H3 …

Histone modifying enzymes are involved in the posttranslational modification of histones
and the epigenetic control of gene expression. They play a critical role in normal …

Breast cancer metastasis to the brain develops after a clinical latency of years to even
decades, suggesting that colonization of the brain is the most challenging step of the …

The etiology of neurodevelopmental disorders (NDDs) remains a challenge for researchers.
Human brain development is tightly regulated and sensitive to cellular alterations caused by …

Early-life iron deficiency (ID) causes long-term neurocognitive impairments and gene
dysregulation that can be partially mitigated by prenatal choline supplementation. The long …

Reelin is a secreted glycoprotein that was initially investigated in the field of neuronal
development. However, in recent decades, its role in the adult brain has become …