miR-212/132 expression and functions: within and beyond the neuronal compartment

A Wanet, A Tacheny, T Arnould… - Nucleic acids …, 2012 - academic.oup.com
During the last two decades, microRNAs (miRNAs) emerged as critical regulators of gene
expression. By modulating the expression of numerous target mRNAs mainly at the post …

[HTML][HTML] Mechanisms of microRNA-132 in central neurodegenerative diseases: A comprehensive review

C Mu, M Gao, W Xu, X Sun, T Chen, H Xu… - Biomedicine & …, 2024 - Elsevier
Abstracts MicroRNA-132 (miR-132) is a highly conserved molecule that plays a crucial
regulatory role in central nervous system (CNS) disorders. The expression levels of miR-132 …

Hippocampal microRNA-132 mediates stress-inducible cognitive deficits through its acetylcholinesterase target

G Shaltiel, M Hanan, Y Wolf, S Barbash… - Brain Structure and …, 2013 - Springer
Diverse stress stimuli induce long-lasting cognitive deficits, but the underlying molecular
mechanisms are still incompletely understood. Here, we report three different stress models …

Changes in readthrough acetylcholinesterase expression modulate amyloid-beta pathology

A Berson, M Knobloch, M Hanan, S Diamant… - Brain, 2008 - academic.oup.com
Alzheimer's disease has long been known to involve cholinergic deficits, but the linkage
between cholinergic gene expression and the Alzheimer's disease amyloid pathology has …

Acetylcholinesterase and apoptosis: a novel perspective for an old enzyme

H Jiang, XJ Zhang - The FEBS journal, 2008 - Wiley Online Library
Acetylcholinesterase is indispensable for terminating acetylcholine‐mediated
neurotransmission at cholinergic synapses. In addition, there is evidence to suggest that …

miR-124 represses ROCK1 expression to promote neurite elongation through activation of the PI3K/Akt signal pathway

X Gu, S Meng, S Liu, C Jia, Y Fang, S Li, C Fu… - Journal of Molecular …, 2014 - Springer
Recent studies have demonstrated an important role for miR-124, the most abundant and
well-conserved brain-specific microRNA (miRNA), in promoting neurite outgrowth and …

Neuronal AChE splice variants and their non‐hydrolytic functions: redefining a target of AChE inhibitors?

M Zimmermann - British journal of pharmacology, 2013 - Wiley Online Library
AChE enzymatic inhibition is a core focus of pharmacological intervention in A lzheimer's
disease (AD). Yet, AChE has also been ascribed non‐hydrolytic functions, which seem …

Aluminum exposure for 60 days at an equivalent human dietary level promotes peripheral dysfunction in rats

CS Martinez, G Vera, JAU Ocio, FM Peçanha… - Journal of inorganic …, 2018 - Elsevier
Aluminum (Al) is a neurotoxic associated with a number of chronic human diseases. We
investigated the effects of Al exposure at doses similar to human dietary levels and at a high …

Dendropanax morbifera Léveille extract ameliorates cadmium-induced impairment in memory and hippocampal neurogenesis in rats

W Kim, HS Yim, DY Yoo, HY Jung, JW Kim… - … and alternative medicine, 2016 - Springer
Background Cadmium leads to learning and memory impairment. Dendropanax morbifera
Léveille stem extract (DMS) reduces cadmium-induced oxidative stress in the hippocampus …

Regional specific alterations in brain acetylcholinesterase activity after repeated blast exposures in mice

M Valiyaveettil, Y Alamneh, S Oguntayo, Y Wei… - Neuroscience …, 2012 - Elsevier
Acetylcholinesterase (AChE) which catalyzes the hydrolysis of the neurotransmitter
acetylcholine has been recognized as one of the major regulators of stress responses after …