The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2),
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …

Reactive oxygen or nitrogen species (ROS/RNS) generated endogenously or in response to
environmental stress have long been implicated in tissue injury in the context of a variety of …

Providing a comprehensive review of reactions of oxidation for different classes of organic
compounds and polymers, and biological processes mediated by free radicals, Oxidation …

The heme biosynthetic and catabolic pathways generate pro-and antioxidant compounds,
and consequently, influence cellular sensitivity to oxidants. Heme precursors (δ …

Iron-derived reactive oxygen species are implicated in the pathogenesis of various vascular
disorders including atherosclerosis, vasculitis, and reperfusion injury. The present studies …

Carbon monoxide (CO), a gaseous second messenger, arises in biological systems during
the oxidative catabolism of heme by the heme oxygenase (HO) enzymes. HO exists as …

Patients with hereditary or secondary hemochromatosis are liable to cardiac and hepatic
failure, and type II diabetes. Despite the highly likely conjecture that iron-mediated tissue …

Oxidized low density lipoprotein (LDL), formed in vivo from presently unknown reactions,
may play a role in atherogenesis. In vitro, transition metals such as iron and copper will …

Atypical hemolytic uremic syndrome (aHUS) is characterized by genetic and acquired
abnormalities of the complement system leading to alternative pathway (AP) overactivation …

Heme oxygenase-1 (HO-1) degrades heme to carbon monoxide (CO), biliverdin, and ferrous
iron. As HO-1 expression is highly increased by stressful conditions, the major role of the …