Immune-checkpoint inhibitors: long-term implications of toxicity

DB Johnson, CA Nebhan, JJ Moslehi… - Nature Reviews Clinical …, 2022 - nature.com
The development of immune-checkpoint inhibitors (ICIs) has heralded a new era in cancer
treatment, enabling the possibility of long-term survival in patients with metastatic disease …

Immune-related adverse events of checkpoint inhibitors

M Ramos-Casals, JR Brahmer, MK Callahan… - Nature reviews Disease …, 2020 - nature.com
Cancer immunotherapies have changed the landscape of cancer treatment during the past
few decades. Among them, immune checkpoint inhibitors, which target PD-1, PD-L1 and …

Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immune checkpoint inhibitor-related adverse events

JR Brahmer, H Abu-Sbeih, PA Ascierto… - Journal for …, 2021 - pmc.ncbi.nlm.nih.gov
Immune checkpoint inhibitors (ICIs) are the standard of care for the treatment of several
cancers. While these immunotherapies have improved patient outcomes in many clinical …

Consensus disease definitions for neurologic immune-related adverse events of immune checkpoint inhibitors

AC Guidon, LB Burton, BK Chwalisz… - Journal for …, 2021 - pmc.ncbi.nlm.nih.gov
Expanding the US Food and Drug Administration–approved indications for immune
checkpoint inhibitors in patients with cancer has resulted in therapeutic success and …

Neurologic adverse events of immune checkpoint inhibitors: a systematic review

A Marini, A Bernardini, GL Gigli, M Valente… - Neurology, 2021 - neurology.org
Objective To define the clinical characteristics, management, and outcome of neurologic
immune-related adverse events (n-irAEs) of immune checkpoint inhibitors (ICIs). Methods …

Peripheral neuropathy and headache in cancer patients treated with immunotherapy and immuno-oncology combinations: the MOUSEION-02 study

A Rizzo, M Santoni, V Mollica, F Logullo… - Expert opinion on …, 2021 - Taylor & Francis
Introduction Treatment-related neurotoxicity is a common side effect in cancer patients.
However, few data are available regarding the risk of several neurotoxicities in patients …

Severe neurological toxicity of immune checkpoint inhibitors: growing spectrum

D Dubey, WS David, KL Reynolds, DF Chute… - Annals of …, 2020 - Wiley Online Library
Expanding use of immune‐checkpoint inhibitors (ICIs) underscores the importance of
accurate diagnosis and timely management of neurological immune‐related adverse events …

Neurological adverse events of immune checkpoint inhibitors and the development of paraneoplastic neurological syndromes

A Farina, M Villagrán-García, A Vogrig… - The Lancet …, 2024 - thelancet.com
Immune checkpoint inhibitors, a class of oncological treatments that enhance antitumour
immunity, can trigger neurological adverse events closely resembling paraneoplastic …

Skeletal muscle and peripheral nerve histopathology in COVID-19

J Suh, SS Mukerji, SI Collens, RF Padera Jr, GS Pinkus… - Neurology, 2021 - neurology.org
Objective To explore the spectrum of skeletal muscle and nerve pathology of patients who
died after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and to …

Neurologic complications of immune checkpoint inhibitors

AM Haugh, JC Probasco… - Expert opinion on drug …, 2020 - Taylor & Francis
Introduction: Immune checkpoint inhibitors (ICI) are associated with a wide spectrum of
neurologic immune-related adverse events (irAEs) including meningo-encephalitis …