The aim of this review is to briefly describe some colorimetric methods that are commonly
used to evaluate a new chemical entity (NCE) on cell cultures in non-clinical oncology …

Given the hazardous nature of many materials and substances, ocular toxicity testing is
required to evaluate the dangers associated with these substances after their exposure to …

The clonogenic or colony formation assay is a widely used method to study the number and
size of cancer cell colonies that remain after irradiation or cytotoxic agent administration and …

The use of cell lines to test the toxicity of aquatic pollutants is a valuable alternative to fish
bioassays. In this study, fibroblast SAF-1 cells from the marine gilthead seabream (Sparus …

Structural mitochondrial damage accompanies the cytotoxic effects of several drugs
including tumor necrosis factor (TNF). Using various inhibitors of mitochondrial electron …

The method for cell number measurement in monolayer cultures by crystal violet staining
published recently by Gillies et al.(RG Gillies, N. Didier, M. Denton (1986) Anal. Biochem …

As a consequence of poor perfusion and elevated acid production, the extracellular pH (pH
ex) of tumors is generally acidic. Despite this, most in vitro experiments are still performed at …

Previous studies have demonstrated a synergistic interaction between rhuMAb HER2 and
the cytotoxic drug cisplatin in human breast and ovarian cancer cells. To define the nature of …

Resistance to anti-cancer chemotherapies often leads to regional failure, and can be caused
by biochemical and/or physiological mechanisms. Biochemical mechanisms include the …

Background: Trastuzumab, a humanized anti-HER2 antibody, increases the clinical benefit
of first-line chemotherapy in patients with metastatic breast cancers that overexpress HER2 …