The regulation and function of lactate dehydrogenase a: therapeutic potential in brain tumor

CJ Valvona, HL Fillmore, PB Nunn… - Brain …, 2016 - Wiley Online Library
There are over 120 types of brain tumor and approximately 45% of primary brain tumors are
gliomas, of which glioblastoma multiforme (GBM) is the most common and aggressive with a …

The evolution of bioinformatics in toxicology: advancing toxicogenomics

CA Afshari, HK Hamadeh, PR Bushel - Toxicological Sciences, 2011 - academic.oup.com
As one reflects back through the past 50 years of scientific research, a significant
accomplishment was the advance into the genomic era. Basic research scientists have …

Hypoxic regulation of lactate dehydrogenase a: interaction between hypoxia-inducible factor 1 and camp response elements (∗)

JD Firth, BL Ebert, PJ Ratcliffe - Journal of Biological Chemistry, 1995 - jbc.org
The oxygen-regulated control system responsible for the induction of erythropoietin (Epo) by
hypoxia is present in most (if not all) cells and operates on other genes, including those …

Post-transcriptional regulation of glyceraldehyde-3-phosphate-dehydrogenase gene expression in rat tissues

M Piechaczyk, JM Blanchard, L Marty… - Nucleic Acids …, 1984 - academic.oup.com
We have isolated and identified cDNA clones containing part of the coding sequence for rat
glyceraldehyde-3-phosphate-dehydrogenase (GAPDH, EC 1.2. 1.12). By using one of these …

Modulation of synapse formation by cyclic adenosine monophosphate

M Nirenberg, S Wilson, H Higashida, A Rotter… - Science, 1983 - science.org
Synapses between neuroblastoma-hybrid cells and myotubes exhibit a high degree of
plasticity. Increase of cyclic adenosine monophosphate (AMP) levels of the hybrid cells for …

Lactate regulates rat male germ cell function through reactive oxygen species

MN Galardo, M Regueira, MF Riera, EH Pellizzari… - PloS one, 2014 - journals.plos.org
Besides giving structural support, Sertoli cells regulate the fate of germ cells by supplying a
variety of factors. These factors include hormones, several pro-and anti-apoptotic agents …

Regulation of tyrosine hydroxylase mRNA by glucocorticoid and cyclic AMP in a rat pheochromocytoma cell line. Isolation of a cDNA clone for tyrosine hydroxylase …

EJ Lewis, AW Tank, N Weiner, DM Chikaraishi - Journal of Biological …, 1983 - jbc.org
Treatment of a subclone of the PC12 pheochromocytoma cell line, PC8b, with either
dexamethasone or 8-bromo cyclic AMP resulted in increased translational activity of tyrosine …

Thyrotropin controls transcription of the thyroglobulin gene.

B Van Heuverswyn, C Streydio, H Brocas… - Proceedings of the …, 1984 - pnas.org
The availability of rat thyroglobulin cDNA clones was exploited to study the regulation of
thyroglobulin gene transcription by thyrotropin (TSH). Groups of rats were subjected to …

Regulation of lactate production by FSH, IL1β, and TNFα in rat Sertoli cells

MF Riera, SB Meroni, GE Gomez… - General and …, 2001 - Elsevier
One of the “nurse cell” functions of Sertoli cells is to provide lactate for the energy production
in spermatocytes and spermatids. The present study shows that, as in porcine Sertoli cells …

Promoter Hypermethylation in Cancer Silences LDHB, Eliminating Lactate Dehydrogenase Isoenzymes 1-4

M Maekawa, T Taniguchi, J Ishikawa… - Clinical …, 2003 - academic.oup.com
LDHA and LDHB (1). Expression of mammalian LDHA and LDHB is regulated during
development and is tissue specific (2, 3); therefore, alterations in the serum LD isoenzyme …