Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

Microvascular endothelial cells in the kidney have been a neglected cell type in sepsis-
induced acute kidney injury (sepsis-AKI) research; yet, they offer tremendous potential as …

Endothelial dysfunction contributes to the pathogenesis of a variety of potentially serious
infectious diseases and syndromes, including sepsis and septic shock, hemolytic-uremic …

Introduction Previous reports suggest that endothelial activation is an important process in
sepsis pathogenesis. We investigated the association between biomarkers of endothelial …

Sepsis, a dysregulated host response to infection that causes life-threatening organ
dysfunction, is a highly heterogeneous syndrome with no specific treatment. Although sepsis …

Septic shock is characterized by increased vascular permeability and hypotension despite
increased cardiac output. Numerous vasoactive cytokines are upregulated during sepsis …

Protection of endothelial integrity has been recognized as a frontline approach to alleviating
sepsis progression, yet no effective agent for preserving endothelial integrity is available …

Objective: To determine the utility of angiopoietin-1 and angiopoietin-2 as potentially novel
biomarkers of morbidity and mortality in patients with severe sepsis. Design: Multicenter …

Neutrophils release neutrophil extracellular traps (NETs) to trap pathogenic microorganisms.
NETs are involved in the inflammatory response and bacterial killing and clearance …

Systemic inflammation plays a pivotal role in a multitude of conditions, including sepsis,
trauma, major surgery and burns. However, comprehensive analysis of the pathophysiology …