The precise functional role of the hippocampus remains a topic of much debate. The
dominant view is that the dorsal (or posterior) hippocampus is implicated in memory and …

There is a growing recognition of the importance of the commensal intestinal microbiota in
the development and later function of the central nervous system. Research using germ-free …

Whether hippocampal neurogenesis persists throughout life in the human brain is not fully
resolved. Here, we demonstrate that hippocampal neurogenesis is persistent through the …

The hippocampus is traditionally thought to transmit contextual information to limbic
structures where it acquires valence. Using freely moving calcium imaging and …

Sex differences are reported in hippocampal plasticity, cognition, and in a number of
disorders that target the integrity of the hippocampus. For example, meta-analyses reveal …

Recent studies using transgenic mice lacking NMDA receptors in the hippocampus
challenge the long-standing hypothesis that hippocampal long-term potentiation-like …

The hippocampus shrinks in late adulthood, leading to impaired memory and increased risk
for dementia. Hippocampal and medial temporal lobe volumes are larger in higher-fit adults …

One literature treats the hippocampus as a purely cognitive structure involved in memory;
another treats it as a regulator of emotion whose dysfunction leads to psychopathology. We …

The dentate gyrus (DG), in addition to its role in learning and memory, is increasingly
implicated in the pathophysiology of anxiety disorders. Here, we show that, dependent on …

The consolidation of context-dependent emotional memory requires communication
between the hippocampus and the basolateral amygdala (BLA), but the mechanisms of this …