Schematic diagram illustrating how the Mu~ i, MutY and MutT proteins reduce accumulation
of 8-oxoguanine residues in DNA. 8-oxoguanine is introduced into DNA by oxidative …

Our studies on the biochemical basis of spontaneous mutations took an interesting and
unexpected turn when we discovered that a small region of amino acid homology between …

II. Evolutionary Changes in Protein Structure............................ A. The Cytochromes c........--------
------------------------------B. The Globins.................................................... C. The …

A quantitative theory of directional mutation pressure proposed in 1962 explained the wide
variation of DNA base composition observed among different bacteria and its small …

ERRORS in the replication of DNA are a major source of spontaneous mutations, and a
number of cellular functions are involved in correction of these errors to keep the frequency …

FIGURE 2. A map of the relative positions of e mutants described in this study. Mutants with
the prefix J were induced by proflavine; mutants with the prefix JD are spontaneous mutants …

On the basis of chemical considerations and model building, the Watson–Crick concept of
complementary base pairing is extended to a wider range of DNA pairs than A–T and G–C …

Nudix hydrolases are found in all classes of organism and hydrolyse a wide range of
organic pyrophosphates, including nucleoside di-and triphosphates, dinucleoside and …

The GO system is an error avoidance pathway devoted to enhancing the fidelity of DNA
replication (31, 35). Although the system has been most fully characterized for Eschenchia …

Oxidative DNA damage is a major cause of cell death and mutagenesis in all aerobic
organisms, and several new oxidative base lesions have been identified in recent years …