Angiogenesis, the formation of new blood vessels, is a complex and dynamic process
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …

Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …

Cancer-associated fibroblasts (CAFs) found in primary and metastatic tumours are highly
versatile, plastic and resilient cells that are actively involved in cancer progression through …

The extracellular matrix (ECM) is one of the major components of tumors that plays multiple
crucial roles, including mechanical support, modulation of the microenvironment, and a …

With only a fraction of patients responding to cancer immunotherapy, a better understanding
of the entire tumor microenvironment is needed. Using single-cell transcriptomics, we chart …

It is currently accepted that cancer-associated fibroblasts (CAF) participate in T-cell
exclusion from tumor nests. To unbiasedly test this, we used single-cell RNA sequencing …

The extracellular matrix (ECM) plays an important role in cancer progression. It can be
divided into the basement membrane (BM) that supports epithelial/endothelial cell behavior …

Among all cells, fibroblasts could be considered the cockroaches of the human body. They
survive severe stress that is usually lethal to all other cells, and they are the only normal cell …

Brain, the major organ of the central nervous system controls and processes most of body
activities. Therefore, the most aggressive brain tumor–glioblastoma and metastases from …

Tumor targeting by nanomedicine-based therapeutics has emerged as a promising
approach to overcome the lack of specificity of conventional chemotherapeutic agents and to …