Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight

JW Vogel, N Corriveau-Lecavalier… - Nature Reviews …, 2023 - nature.com
Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …

The margins of the language network in the brain

I Hertrich, S Dietrich, H Ackermann - Frontiers in Communication, 2020 - frontiersin.org
This review paper summarizes the various brain modules that are involved in speech and
language communication in addition to a left-dominant “core” language network that, for the …

Temporopolar regions of the human brain

MM Mesulam - Brain, 2023 - academic.oup.com
Following prolonged neglect during the formative decades of behavioural neurology, the
temporopolar region has become a site of vibrant research on the neurobiology of cognition …

The Wernicke conundrum revisited: evidence from connectome-based lesion-symptom map**

W Matchin, DB den Ouden, G Hickok, AE Hillis… - Brain, 2022 - academic.oup.com
Wernicke's area has been assumed since the 1800s to be the primary region supporting
word and sentence comprehension. However, in 2015 and 2019, Mesulam and colleagues …

Different patterns of functional network reorganization across the variants of primary progressive aphasia: a graph-theoretic analysis

Y Tao, B Ficek, B Rapp, K Tsapkini - Neurobiology of aging, 2020 - Elsevier
Primary progressive aphasia (PPA) is a neurodegenerative syndrome with three main
variants (nonfluent, logopenic, semantic) that are identified primarily based on language …

Breakdown of category-specific word representations in a brain-constrained neurocomputational model of semantic dementia

Y Shtyrov, A Efremov, A Kuptsova, T Wennekers… - Scientific Reports, 2023 - nature.com
The neurobiological nature of semantic knowledge, ie, the encoding and storage of
conceptual information in the human brain, remains a poorly understood and hotly debated …

Multivariate analysis reveals anatomical correlates of naming errors in primary progressive aphasia

R Bruffaerts, J Schaeverbeke, AS De Weer… - Neurobiology of …, 2020 - Elsevier
Primary progressive aphasia (PPA) is an overarching term for a heterogeneous group of
neurodegenerative diseases which affect language processing. Impaired picture naming …

Altered structural brain networks in linguistic variants of frontotemporal dementia

S Nigro, B Tafuri, D Urso, R De Blasi, A Cedola… - Brain Imaging and …, 2021 - Springer
Semantic (svPPA) and nonfluent (nfvPPA) variants of primary progressive aphasia (PPA)
have recently been associated with distinct patterns of white matter and functional network …

Cortical tracking of the speech envelope in logopenic variant primary progressive aphasia

HR Dial, GN Gnanateja, RS Tessmer… - Frontiers in human …, 2021 - frontiersin.org
Logopenic variant primary progressive aphasia (lvPPA) is a neurodegenerative language
disorder primarily characterized by impaired phonological processing. Sentence repetition …

[HTML][HTML] Resting functional connectivity in the semantic appraisal network predicts accuracy of emotion identification

WFZ Yang, G Toller, S Shdo, SA Kotz, J Brown… - NeuroImage: Clinical, 2021 - Elsevier
Objective Structural and task-based functional studies associate emotion reading with
frontotemporal brain networks, though it remains unclear whether functional connectivity …