Over the past decade the number and variety of protein post-translational modifications that
have been detected and characterized in bacteria have rapidly increased. Most post …

The misuse of antibiotics combined with a lack of newly developed ones is the main
contributors to the current antibiotic resistance crisis. There is a dire need for new and …

Small molecules have been classically developed to inhibit enzyme activity; however, new
classes of small molecules that endow new functions to enzymes via proximity-mediated …

In recent years, with the successful development of proteolysis-targeting chimeric molecules
(PROTACs), the potential of heterobifunctional molecules to contribute to reenvisioning drug …

Background We aim to identify the molecular mechanisms for curcumin's anti-depressant
properties, including genes, transcription factors, and miRNAs. Methods The Comparative …

Abstract Targeted Protein Modification (TPM) is an umbrella term encompassing numerous
tools and approaches that use bifunctional agents to induce a desired modification over the …

The utilization of proximity-mediated effects to perturb pathogenic proteins of interest (POIs)
has emerged as a powerful strategic alternative to conventional drug design approaches …

Recombinant proteins are of paramount importance for research, industrial and medical use.
Numerous expression chassis are available for recombinant protein production, and while …

After harvest, potato tubers undergo an important period of dormancy, which significantly
impacts potato quality and seed vigor. StSN2 has been reported as a key gene for …

Proteins are the most common types of biomarkers used in breast cancer (BC) theranostics
and management. By definition, a biomarker must be a relevant, objective, stable, and …