Modern analytical techniques in metabolomics analysis

A Zhang, H Sun, P Wang, Y Han, X Wang - Analyst, 2012 - pubs.rsc.org
Metabolomics is the comprehensive assessment of endogenous metabolites and attempts to
systematically identify and quantify metabolites from a biological sample. Small-molecule …

Recent trends in application of chemometric methods for GC-MS and GCŨGC-MS-based metabolomic studies

N Feizi, FS Hashemi-Nasab, F Golpelichi… - TrAC Trends in …, 2021 - Elsevier
Metabolomics is the science of studying small molecules (metabolites) in biological systems
with the aim of getting insight into cells, biofluids and organisms. Chemometric methods are …

Quantitative metabolomics based on gas chromatography mass spectrometry: status and perspectives

MM Koek, RH Jellema, J van der Greef, AC Tas… - Metabolomics, 2011 - Springer
Metabolomics involves the unbiased quantitative and qualitative analysis of the complete set
of metabolites present in cells, body fluids and tissues (the metabolome). By analyzing …

Recent developments in the application of comprehensive two-dimensional gas chromatography

M Adahchour, J Beens, UAT Brinkman - Journal of Chromatography A, 2008 - Elsevier
The literature on comprehensive two-dimensional gas chromatography (GC× GC) is
reviewed, with emphasis on application-oriented studies published in the period 2004 …

[HTML][HTML] Advances in mass spectrometry-based multi-scale metabolomic methodologies and their applications in biological and clinical investigations

Z Wang, H Zhu, W **ong - Science Bulletin, 2023 - Elsevier
Metabolomics is a nascent field of inquiry that emerged in the late 20 th century. It
encompasses the comprehensive profiling of metabolites across a spectrum of organisms …

Comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry for metabonomics: Biomarker discovery for diabetes mellitus

X Li, Z Xu, X Lu, X Yang, P Yin, H Kong, Y Yu… - Analytica Chimica Acta, 2009 - Elsevier
Comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry
(GC× GC–TOFMS) coupled with pattern recognition methods was applied to analyze plasma …

Current trends and future requirements for the mass spectrometric investigation of microbial, mammalian and plant metabolomes

WB Dunn - Physical biology, 2008 - iopscience.iop.org
The functional levels of biological cells or organisms can be separated into the genome,
transcriptome, proteome and metabolome. Of these the metabolome offers specific …

Current and emerging mass-spectrometry technologies for metabolomics

M Bedair, LW Sumner - TrAC Trends in Analytical Chemistry, 2008 - Elsevier
Mass spectrometry (MS) has secured a central role in metabolomics that is predicted to grow
based upon continuous developments and improvements in MS technologies. This article …

Data analysis tool for comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry

S Castillo, I Mattila, J Miettinen, M Oresic… - Analytical …, 2011 - ACS Publications
Data processing and identification of unknown compounds in comprehensive two-
dimensional gas chromatography combined with time-of-flight mass spectrometry (GC× …

ChroMATHography: solving chromatographic issues with mathematical models and intuitive graphics

JM Amigo, T Skov, R Bro - Chemical reviews, 2010 - ACS Publications
The evolution of hyphenated chromatographic systems for the detection, quantification,
and/or identification of compounds has become one of the most important developments in …