Oligodendrocytes generate multiple layers of myelin membrane around axons of the central
nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve …

Rho GTPases are key regulators of cytoskeletal dynamics and affect many cellular
processes, including cell polarity, migration, vesicle trafficking and cytokinesis. These …

The lack of therapies for progressive multiple sclerosis highlights the need to understand the
regenerative process of remyelination that can follow CNS demyelination. This involves an …

Oligodendrocytes are the myelinating glia of the central nervous system. Myelination of
axons allows rapid saltatory conduction of nerve impulses and contributes to axonal …

Rho/Rac proteins constitute a subgroup of the Ras superfamily of GTP hydrolases. Although
originally implicated in the control of cytoskeletal events, it is currently known that these …

Myelinated nerve fibers are essential for the rapid propagation of action potentials by
saltatory conduction. They form as the result of reciprocal interactions between axons and …

Establishment of oligodendrocyte identity is crucial for subsequent events of myelination in
the CNS. Here, we demonstrate that activation of ATP-dependent SWI/SNF chromatin …

Central nervous system (CNS) myelination by oligodendrocytes (OLs) is a highly
orchestrated process involving well-defined steps from specification of neural stem cells into …

Myelin is essential in vertebrates for the rapid propagation of action potentials, but the
molecular mechanisms driving its formation remain largely unknown. Here we show that the …

During CNS development, oligodendrocytes wrap their plasma membrane around axons to
generate multilamellar myelin sheaths. To drive growth at the leading edge of myelin at the …