Introduction of fluorine and fluorine‐containing functional groups
T Liang, CN Neumann, T Ritter - … Chemie International Edition, 2013 - Wiley Online Library
Over the past decade, the most significant, conceptual advances in the field of fluorination
were enabled most prominently by organo‐and transition‐metal catalysis. The most …
were enabled most prominently by organo‐and transition‐metal catalysis. The most …
Round, round we go–strategies for enzymatic cofactor regeneration
S Mordhorst, JN Andexer - Natural product reports, 2020 - pubs.rsc.org
Covering: up to the beginning of 2020 Enzymes depending on cofactors are essential in
many biosynthetic pathways of natural products. They are often involved in key steps …
many biosynthetic pathways of natural products. They are often involved in key steps …
Enzyme function prediction using contrastive learning
Enzyme function annotation is a fundamental challenge, and numerous computational tools
have been developed. However, most of these tools cannot accurately predict functional …
have been developed. However, most of these tools cannot accurately predict functional …
Genomic basis for natural product biosynthetic diversity in the actinomycetes
M Nett, H Ikeda, BS Moore - Natural product reports, 2009 - pubs.rsc.org
Covering: up to mid-2009 The phylum Actinobacteria hosts diverse high G+ C, Gram-
positive bacteria that have evolved a complex chemical language of natural product …
positive bacteria that have evolved a complex chemical language of natural product …
Enzymatic halogenation and dehalogenation reactions: pervasive and mechanistically diverse
Naturally produced halogenated compounds are ubiquitous across all domains of life where
they perform a multitude of biological functions and adopt a diversity of chemical structures …
they perform a multitude of biological functions and adopt a diversity of chemical structures …
Methyltransferases: functions and applications
E Abdelraheem, B Thair, RF Varela… - …, 2022 - Wiley Online Library
In this review the current state‐of‐the‐art of S‐adenosylmethionine (SAM)‐dependent
methyltransferases and SAM are evaluated. Their structural classification and diversity is …
methyltransferases and SAM are evaluated. Their structural classification and diversity is …
Development of halogenase enzymes for use in synthesis
J Latham, E Brandenburger, SA Shepherd… - Chemical …, 2018 - ACS Publications
Nature has evolved halogenase enzymes to regioselectively halogenate a diverse range of
biosynthetic precursors, with the halogens introduced often having a profound effect on the …
biosynthetic precursors, with the halogens introduced often having a profound effect on the …
Halogenases: a palette of emerging opportunities for synthetic biology–synthetic chemistry and C–H functionalisation
C Crowe, S Molyneux, SV Sharma, Y Zhang… - Chemical Society …, 2021 - pubs.rsc.org
The enzymatic generation of carbon–halogen bonds is a powerful strategy used by both
nature and synthetic chemists to tune the bioactivity, bioavailability and reactivity of …
nature and synthetic chemists to tune the bioactivity, bioavailability and reactivity of …
Enzymatic fluorination and biotechnological developments of the fluorinase
Despite a long and distinguished history focused on the isolation and structural elucidation
of secondary metabolites from all classes of organisms, organic chemists have only securely …
of secondary metabolites from all classes of organisms, organic chemists have only securely …
[HTML][HTML] Novel functionalized phenyl acetate derivatives of benzo [e]-bispyrone fused hybrids: Synthesis and biological activities
Eighteen novel functionalized phenyl acetate derivatives of benzo [e]-bispyrone fused
hybrids and their three precursors are developed in this study. The precursor acetic acid …
hybrids and their three precursors are developed in this study. The precursor acetic acid …