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Metal binding of Alzheimer's amyloid-β and its effect on peptide self-assembly
A Abelein - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus Metal ions have been identified as key factors modulating the aggregation of
amyloid-β peptide (Aβ) implicated in Alzheimer's disease (AD). The presence of elevated …
amyloid-β peptide (Aβ) implicated in Alzheimer's disease (AD). The presence of elevated …
Marine organisms as a rich source of biologically active peptides
MWFS Macedo, NB Cunha, JA Carneiro… - Frontiers in Marine …, 2021 - frontiersin.org
Oceanic environments are one of the largest sources of bioactive molecules, due to the high
degree of biodiversity and the innumerable ecological relationships established between …
degree of biodiversity and the innumerable ecological relationships established between …
Molecular structure of Cu (II)-bound amyloid-β monomer implicated in inhibition of peptide self-assembly in Alzheimer's disease
A Abelein, S Ciofi-Baffoni, C Mörman, R Kumar… - Jacs Au, 2022 - ACS Publications
Metal ions, such as copper and zinc ions, have been shown to strongly modulate the self-
assembly of the amyloid-β (Aβ) peptide into insoluble fibrils, and elevated concentrations of …
assembly of the amyloid-β (Aβ) peptide into insoluble fibrils, and elevated concentrations of …
[HTML][HTML] High-yield production of a super-soluble miniature spidroin for biomimetic high-performance materials
B Schmuck, G Greco, A Barth, NM Pugno, J Johansson… - Materials Today, 2021 - Elsevier
The mechanical properties of artificial spider silks are approaching a stage where
commercial applications become realistic. However, the yields of recombinant silk proteins …
commercial applications become realistic. However, the yields of recombinant silk proteins …
Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain
Protein misfolding can generate toxic intermediates, which underlies several devastating
diseases, such as Alzheimer's disease (AD). The surface of AD-associated amyloid-β …
diseases, such as Alzheimer's disease (AD). The surface of AD-associated amyloid-β …
Intravenous treatment with a molecular chaperone designed against β-amyloid toxicity improves Alzheimer's disease pathology in mouse models
S Manchanda, L Galan-Acosta, A Abelein, S Tambaro… - Molecular Therapy, 2023 - cell.com
Attempts to treat Alzheimer's disease with immunotherapy against the β-amyloid (Aβ)
peptide or with enzyme inhibitors to reduce Aβ production have not yet resulted in effective …
peptide or with enzyme inhibitors to reduce Aβ production have not yet resulted in effective …
High-yield production of amyloid-β peptide enabled by a customized spider silk domain
During storage in the silk gland, the N-terminal domain (NT) of spider silk proteins
(spidroins) keeps the aggregation-prone repetitive region in solution at extreme …
(spidroins) keeps the aggregation-prone repetitive region in solution at extreme …
Intravenous chaperone treatment of late-stage Alzheimer´ s disease (AD) mouse model affects amyloid plaque load, reactive gliosis and AD-related genes
R Zhang, M Ohshima, D Brodin, Y Wang… - Translational …, 2024 - nature.com
Abstract Treatment strategies that are efficient against established Alzheimer's disease (AD)
are needed. BRICHOS is a molecular chaperone domain that prevents amyloid fibril …
are needed. BRICHOS is a molecular chaperone domain that prevents amyloid fibril …
Doing what spiders cannot—A road map to supreme artificial silk fibers
J Johansson, A Rising - ACS nano, 2021 - ACS Publications
Fabricating artificial spider silk fibers in bulk scale has been a major goal in materials
science for centuries. Two main routes have emerged for making such fibers. One method …
science for centuries. Two main routes have emerged for making such fibers. One method …
Deciphering the morphological difference of Amyloid-β fibrils in familial and sporadic Alzheimer's diseases
The aggregation of amyloid-β (Aβ) into amyloid fibrils is the major pathological hallmark of
Alzheimer's disease (AD). Aβ fibrils can adopt a variety of morphologies, the relative …
Alzheimer's disease (AD). Aβ fibrils can adopt a variety of morphologies, the relative …