Analytical methods in lipidomics and their applications

M Li, L Yang, Y Bai, H Liu - Analytical chemistry, 2014 - ACS Publications
As a branch of metabolomics, lipidomics is aimed at full analysis of lipid species and their
biological roles with respect to health and diseases and has attracted increasing attention of …

The GAPDH redox switch safeguards reductive capacity and enables survival of stressed tumour cells

D Talwar, CG Miller, J Grossmann, L Szyrwiel… - Nature …, 2023 - nature.com
Abstract Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is known to contain an
active-site cysteine residue undergoing oxidation in response to hydrogen peroxide, leading …

Novel MS-based approaches and applications in food metabolomics

C Ibáñez, V García-Cañas, A Valdés, C Simó - TrAC Trends in Analytical …, 2013 - Elsevier
This article gives an overview of some of the most recent trends in mass-spectrometry (MS)-
based approaches and their application in food metabolomics. MS is a powerful analytical …

Fast deisoto** algorithm and its implementation in the MSFragger search engine

GC Teo, DA Polasky, F Yu… - Journal of proteome …, 2020 - ACS Publications
Deisoto**, or the process of removing peaks in a mass spectrum resulting from the
incorporation of naturally occurring heavy isotopes, has long been used to reduce …

MIND4OLIGOS: Determining the Monoisotopic Mass of Oligonucleotides Observed in High-Resolution Mass Spectrometry

P Prostko, P Radziński, M Ciach, Y Liu… - Analytical …, 2024 - ACS Publications
Oligonucleotide therapeutics have emerged as an important class of drugs offering targeted
therapeutic strategies that complement traditional modalities, such as monoclonal …

Multiscale biochemical map** of the brain through deep-learning-enhanced high-throughput mass spectrometry

YR **e, DC Castro, SS Rubakhin, TJ Trinklein… - Nature …, 2024 - nature.com
Spatial omics technologies can reveal the molecular intricacy of the brain. While mass
spectrometry imaging (MSI) provides spatial localization of compounds, comprehensive …

IsoSpec: Hyperfast fine structure calculator

MK Łacki, M Startek, D Valkenborg… - Analytical chemistry, 2017 - ACS Publications
As high-resolution mass spectrometry (HRMS) becomes increasingly available, the need of
software tools capable of handling more complex data is surging. The complexity of the …

Complete molecular weight profiling of low-molecular weight heparins using size exclusion chromatography-ion suppressor-high-resolution mass spectrometry

J Zaia, K Khatri, J Klein, C Shao, Y Sheng… - Analytical …, 2016 - ACS Publications
Low-molecular weight heparins (LMWH) prepared by partial depolymerization of
unfractionated heparin are used globally to treat coagulation disorders on an outpatient …

Software for peak finding and elemental composition assignment for glycosaminoglycan tandem mass spectra

JD Hogan, JA Klein, J Wu, P Chopra, GJ Boons… - Molecular & Cellular …, 2018 - ASBMB
Glycosaminoglycans (GAGs) covalently linked to proteoglycans (PGs) are characterized by
repeating disaccharide units and variable sulfation patterns along the chain. GAG length …