Abstract The Ser/Thr kinase mechanistic target of rapamycin (mTOR) is a central regulator of
cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such …

Abstract The American Joint Committee on Cancer (AJCC) staging system for all cancer
sites, including gastroenteropancreatic neuroendocrine tumors (GEP‐NETs), is meant to be …

Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-
related processes of replication stress, mitotic errors, spindle multipolarity and breakage …

This ENETS guidance paper for well‐differentiated nonfunctioning pancreatic
neuroendocrine tumours (NF‐Pan‐NET) has been developed by a multidisciplinary working …

This ENETS guidance paper aims to provide practical advice to clinicians for the diagnosis,
treatment and follow‐up of functioning syndromes in pancreatic neuroendocrine tumours …

Neuroendocrine neoplasms (NENs) arise from the diffuse neuroendocrine cell system and
may occur at many different disease sites. Most frequently, these neoplasms occur in the …

Background & Aims Next-generation sequencing (NGS) of pancreatic cyst fluid is a useful
adjunct in the assessment of patients with pancreatic cyst. However, previous studies have …

The classification of neuroendocrine neoplasms (NENs) differs between organ systems and
currently causes considerable confusion. A uniform classification framework for NENs at any …

Cancer is driven by genetic change, and the advent of massively parallel sequencing has
enabled systematic documentation of this variation at the whole-genome scale,–. Here we …

This manuscript is the result of the North American Neuroendocrine Tumor Society
consensus conference on the surgical management of pancreatic neuroendocrine tumors …