Drug repurposing for viral cancers: A paradigm of machine learning, deep learning, and virtual screening‐based approaches
Cancer management is major concern of health organizations and viral cancers account for
approximately 15.4% of all known human cancers. Due to large number of patients, efficient …
approximately 15.4% of all known human cancers. Due to large number of patients, efficient …
Genetics and precision genomics approaches to pulmonary hypertension
Considerable progress has been made in the genomics of pulmonary arterial hypertension
(PAH) since the 6th World Symposium on Pulmonary Hypertension, with the identification of …
(PAH) since the 6th World Symposium on Pulmonary Hypertension, with the identification of …
Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension
YY Tai, Q Yu, Y Tang, W Sun, NJ Kelly… - Science translational …, 2024 - science.org
Hypoxic reprogramming of vasculature relies on genetic, epigenetic, and metabolic circuitry,
but the control points are unknown. In pulmonary arterial hypertension (PAH), a disease …
but the control points are unknown. In pulmonary arterial hypertension (PAH), a disease …
Harnessing big data to advance treatment and understanding of pulmonary hypertension
Pulmonary hypertension is a complex disease with multiple causes, corresponding to
phenotypic heterogeneity and variable therapeutic responses. Advancing understanding of …
phenotypic heterogeneity and variable therapeutic responses. Advancing understanding of …
Endothelial senescence: a new age in pulmonary hypertension
MK Culley, SY Chan - Circulation research, 2022 - Am Heart Assoc
Pulmonary hypertension is an enigmatic, deleterious disease driven by multiple
heterogeneous causes with a burgeoning proportion of older patients with complex, chronic …
heterogeneous causes with a burgeoning proportion of older patients with complex, chronic …
Lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension
Vascular inflammation regulates endothelial pathophenotypes, particularly in pulmonary
arterial hypertension (PAH). Dysregulated lysosomal activity and cholesterol metabolism …
arterial hypertension (PAH). Dysregulated lysosomal activity and cholesterol metabolism …
CytoCellDB: a comprehensive resource for exploring extrachromosomal DNA in cancer cell lines
Recently, the cancer community has gained a heightened awareness of the roles of
extrachromosomal DNA (ecDNA) in cancer proliferation, drug resistance and epigenetic …
extrachromosomal DNA (ecDNA) in cancer proliferation, drug resistance and epigenetic …
An emerging strategy for targeted therapy of pulmonary arterial hypertension: Vasodilation plus vascular remodeling inhibition
L Hu, C Zhao, Z Chen, G Hu, X Li, Q Li - Drug Discovery Today, 2022 - Elsevier
Highlights•The pathology of PAH is characterized by increased mPAP and elevated PVR on
account of vasoconstriction and vascular remodeling.•Current medications primarily …
account of vasoconstriction and vascular remodeling.•Current medications primarily …
Differential responses of pulmonary vascular cells from PAH patients and controls to TNFα and the effect of the BET inhibitor JQ1
Background Pulmonary arterial hypertension (PAH) encompasses a group of diseases
characterized by raised pulmonary vascular resistance, resulting from vascular remodelling …
characterized by raised pulmonary vascular resistance, resulting from vascular remodelling …
Machine-learning-guided reaction kinetics prediction towards solvent identification for chemical absorption of carbonyl sulfide
Exploring solvents for chemical absorption of carbonyl sulfide (COS) is largely hindered
because of challenging study of reaction kinetics by means of either experimental or …
because of challenging study of reaction kinetics by means of either experimental or …