RIG‐I is our first line of defense against RNA viruses, serving as a pattern recognition
receptor that identifies molecular features common among dsRNA and ssRNA viral …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread in
humans in almost every country, causing the disease COVID-19. Since the start of the …

Inflammasomes are multiprotein signalling platforms that control the inflammatory response
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …

The innate immune system utilizes pattern-recognition receptors (PRRs) to detect the
invasion of pathogens and initiate host antimicrobial responses such as the production of …

ABSTRACT STING (stimulator of interferon genes) is known to control the induction of innate
immune genes in response to the recognition of cytosolic DNA species, including the …

NF-κB transcription factors are critical regulators of immunity, stress responses, apoptosis
and differentiation. A variety of stimuli coalesce on NF-κB activation, which can in turn …

The innate immune system has a key role in the mammalian immune response. Recent
research has demonstrated that mitochondria participate in a broad range of innate immune …

The innate immune system constitutes the first line of defense against invading microbial
pathogens and relies on a large family of pattern recognition receptors (PRRs), which detect …

Innate immunity is the first line of defense against invading pathogens. A family of Toll-like
receptors (TLRs) acts as primary sensors that detect a wide variety of microbial components …

The mammalian innate immune system detects the presence of microbial infection through
germ line-encoded pattern recognition receptors (PRRs). Toll-like receptors, retinoic acid …