Diabetes results from the inability of pancreatic islets to maintain blood glucose
concentrations within a normal physiological range. Clinical features are usually not …

The epidemic of diabetes mellitus (DM) necessitates the development of novel therapeutic
and preventative strategies to attenuate complications of this debilitating disease. Diabetic …

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a member of the
betacoronavirus family, which causes COVID-19 disease. SARS-CoV-2 pathogenicity in …

Growing evidence indicates that microRNAs (miRNAs) have a key role in processes
involved in type 1 diabetes mellitus (T1DM) pathogenesis, including immune system …

Aims/hypothesis Improved biomarkers are acutely needed for the detection of develo**
type 1 diabetes, prior to critical loss of beta cell mass. We previously demonstrated that …

Type 1 diabetes is a chronic autoimmune disease which results in inefficient regulation of
glucose homeostasis and can lead to different vascular comorbidities through life. In this …

Diabetes mellitus (DM), a complex metabolic disease, has become a global threat to human
health worldwide. Over the past decades, an enormous amount of effort has been devoted to …

Type-1 diabetes mellitus (T1DM) is one of the most well-defined and complex metabolic
disorders, characterized by hyperglycemia, with a constantly increasing incidence in …

We investigated plasma microRNA (miRNA) profiles associated with variation of
hyperglycemia, measured as hemoglobin A1c (HbA1c), in two panels of patients with type 1 …

The pathogenesis of hyperglycemia observed in most forms of diabetes is intimately tied to
the islet β cell. Impairments in propeptide processing and secretory function, along with the …