Impact of the Human Cell Atlas on medicine
Single-cell atlases promise to provide a 'missing link'between genes, diseases and
therapies. By identifying the specific cell types, states, programs and contexts where disease …
therapies. By identifying the specific cell types, states, programs and contexts where disease …
Lung adenocarcinoma promotion by air pollutants
A complete understanding of how exposure to environmental substances promotes cancer
formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two …
formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two …
Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness
Clear cell renal cell carcinomas (ccRCCs) represent∼ 75% of RCC cases and account for
most RCC-associated deaths. Inter-and intratumoral heterogeneity (ITH) results in varying …
most RCC-associated deaths. Inter-and intratumoral heterogeneity (ITH) results in varying …
Map** the temporal and spatial dynamics of the human endometrium in vivo and in vitro
The endometrium, the mucosal lining of the uterus, undergoes dynamic changes throughout
the menstrual cycle in response to ovarian hormones. We have generated dense single-cell …
the menstrual cycle in response to ovarian hormones. We have generated dense single-cell …
Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia
Abstract KMT2A-rearranged infant ALL is an aggressive childhood leukemia with poor
prognosis. Here, we investigated the developmental state of KMT2A-rearranged infant B-cell …
prognosis. Here, we investigated the developmental state of KMT2A-rearranged infant B-cell …
Diagnostic classification of childhood cancer using multiscale transcriptomics
The causes of pediatric cancers' distinctiveness compared to adult-onset tumors of the same
type are not completely clear and not fully explained by their genomes. In this study, we …
type are not completely clear and not fully explained by their genomes. In this study, we …
Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours
L Custers, E Khabirova, THH Coorens… - Nature …, 2021 - nature.com
Malignant rhabdoid tumour (MRT) is an often lethal childhood cancer that, like many
paediatric tumours, is thought to arise from aberrant fetal development. The embryonic root …
paediatric tumours, is thought to arise from aberrant fetal development. The embryonic root …
The tumor microenvironment and immune targeting therapy in pediatric renal tumors
AB Hont, B Dumont, KS Sutton… - Pediatric blood & …, 2023 - Wiley Online Library
This review highlights the role of several immunomodulating elements contributing to the
tumor microenvironment of various pediatric renal tumors including Wilms tumor. The roles …
tumor microenvironment of various pediatric renal tumors including Wilms tumor. The roles …
Scalable querying of human cell atlases via a foundational model reveals commonalities across fibrosis-associated macrophages
Single-cell RNA-seq (scRNA-seq) studies have profiled over 100 million human cells across
diseases, developmental stages, and perturbations to date. A singular view of this vast and …
diseases, developmental stages, and perturbations to date. A singular view of this vast and …
Deep learning exploration of single-cell and spatially resolved cancer transcriptomics to unravel tumour heterogeneity
Tumour heterogeneity is one of the critical confounding aspects in decoding tumour growth.
Malignant cells display variations in their gene transcription profiles and mutation spectra …
Malignant cells display variations in their gene transcription profiles and mutation spectra …