The physiological functions of human peroxisomes
RJA Wanders, M Baes, D Ribeiro… - Physiological …, 2023 - journals.physiology.org
Peroxisomes are subcellular organelles that play a central role in human physiology by
catalyzing a range of unique metabolic functions. The importance of peroxisomes for human …
catalyzing a range of unique metabolic functions. The importance of peroxisomes for human …
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles
RQ Yao, C Ren, ZF **a, YM Yao - Autophagy, 2021 - Taylor & Francis
The structural integrity and functional stability of organelles are prerequisites for the viability
and responsiveness of cells. Dysfunction of multiple organelles is critically involved in the …
and responsiveness of cells. Dysfunction of multiple organelles is critically involved in the …
The industrial yeast Pichia pastoris is converted from a heterotroph into an autotroph capable of growth on CO2
The methylotrophic yeast Pichia pastoris is widely used in the manufacture of industrial
enzymes and pharmaceuticals. Like most biotechnological production hosts, P. pastoris is …
enzymes and pharmaceuticals. Like most biotechnological production hosts, P. pastoris is …
The cell biology of the retinal pigment epithelium
A Lakkaraju, A Umapathy, LX Tan, L Daniele… - Progress in retinal and …, 2020 - Elsevier
The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells,
strategically situated between the photoreceptors and the choroid, is the primary caretaker of …
strategically situated between the photoreceptors and the choroid, is the primary caretaker of …
PEX5 translocation into and out of peroxisomes drives matrix protein import
ML Skowyra, TA Rapoport - Molecular cell, 2022 - cell.com
Peroxisomes are ubiquitous organelles whose dysfunction causes fatal human diseases.
Most peroxisomal enzymes are imported from the cytosol by the receptor PEX5, which …
Most peroxisomal enzymes are imported from the cytosol by the receptor PEX5, which …
ATM functions at the peroxisome to induce pexophagy in response to ROS
Peroxisomes are highly metabolic, autonomously replicating organelles that generate
reactive oxygen species (ROS) as a by-product of fatty acid β-oxidation. Consequently, cells …
reactive oxygen species (ROS) as a by-product of fatty acid β-oxidation. Consequently, cells …
[HTML][HTML] Human disorders of peroxisome metabolism and biogenesis
HR Waterham, S Ferdinandusse… - Biochimica Et Biophysica …, 2016 - Elsevier
Peroxisomes are dynamic organelles that play an essential role in a variety of cellular
catabolic and anabolic metabolic pathways, including fatty acid alpha-and beta-oxidation …
catabolic and anabolic metabolic pathways, including fatty acid alpha-and beta-oxidation …
Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets
Macroautophagy is an intracellular degradation system by which cytoplasmic materials are
enclosed by the autophagosome and delivered to the lysosome. Autophagosome formation …
enclosed by the autophagosome and delivered to the lysosome. Autophagosome formation …
A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning
CRM1 is a highly conserved, RanGTPase-driven exportin that carries proteins and RNPs
from the nucleus to the cytoplasm. We now explored the cargo-spectrum of CRM1 in depth …
from the nucleus to the cytoplasm. We now explored the cargo-spectrum of CRM1 in depth …
A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS
Subcellular localization is emerging as an important mechanism for mTORC1 regulation. We
report that the tuberous sclerosis complex (TSC) signalling node, TSC1, TSC2 and Rheb …
report that the tuberous sclerosis complex (TSC) signalling node, TSC1, TSC2 and Rheb …