Flavin-dependent monooxygenases catalyze a wide variety of redox reactions in important
biological processes and are responsible for the synthesis of highly complex natural …

Highlights•The versatile chemistry of the flavin cofactor underpins a wide range of enzyme
reactions.•New flavin species have recently been discovered, including prenylated flavins …

Pollution, accidents, and misinformation have earned the pharmaceutical and chemical
industry a poor public reputation, despite their undisputable importance to society …

Amino groups derived from naturally abundant amino acids or (di) amines can be used as
“shuttles” in nature for oxygen transfer to provide intermediates or products comprising NO …

Highlights•Monooxygenases (MOs) face a challenging reaction, requiring the coordination
of three substrates by the same active site.•To address this challenge, these enzymes …

Acinetobacter baumannii is a Gram-negative opportunistic pathogen that causes
nosocomial infections, especially among immunocompromised individuals. The rise of …

Zonocerus variegatus, or the painted grasshopper, is a food crop pest endemic in Western
and Central Africa. Agricultural industries in these regions rely heavily on natural defense …

Allicin is a component of the characteristic smell and flavor of garlic (Allium sativum). A flavin-
containing monooxygenase (FMO) produced by A. sativum (AsFMO) was previously …

Aspergillus fumigatus siderophore (SidA), a member of class B flavin-dependent
monooxygenases, was selected as a model system to investigate the hydroxylation …

The soil actinomycete Kutzneria sp. 744 produces a class of highly decorated
hexadepsipeptides, which represent a new chemical scaffold that has both antimicrobial and …