Immune modulation by bacterial outer membrane vesicles

M Kaparakis-Liaskos, RL Ferrero - Nature Reviews Immunology, 2015 - nature.com
Gram-negative bacteria shed extracellular outer membrane vesicles (OMVs) during their
normal growth both in vitro and in vivo. OMVs are spherical, bilayered membrane …

Outer membrane vesicle vaccines

F Micoli, CA MacLennan - Seminars in immunology, 2020 - Elsevier
Abstract Outer Membrane Vesicles (OMV) have received increased attention in recent years
as a vaccine platform against bacterial pathogens. OMV from Neisseria meningitidis …

Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response

OY Kim, HT Park, NTH Dinh, SJ Choi, J Lee… - Nature …, 2017 - nature.com
Gram-negative bacteria actively secrete outer membrane vesicles, spherical nano-meter-
sized proteolipids enriched with outer membrane proteins, to the surroundings. Outer …

Applying extracellular vesicles based therapeutics in clinical trials–an ISEV position paper

T Lener, M Gimona, L Aigner, V Börger… - Journal of …, 2015 - Taylor & Francis
Extracellular vesicles (EVs), such as exosomes and microvesicles, are released by different
cell types and participate in physiological and pathophysiological processes. EVs mediate …

Modulating antibacterial immunity via bacterial membrane-coated nanoparticles

W Gao, RH Fang, S Thamphiwatana, BT Luk, J Li… - Nano …, 2015 - ACS Publications
Synthetic nanoparticles coated with cellular membranes have been increasingly explored to
harness natural cell functions toward the development of novel therapeutic strategies …

Gram-negative and Gram-positive bacterial extracellular vesicles

JH Kim, J Lee, J Park, YS Gho - Seminars in cell & developmental biology, 2015 - Elsevier
Like mammalian cells, Gram-negative and Gram-positive bacteria release nano-sized
membrane vesicles into the extracellular environment either in a constitutive manner or in a …

Therapeutic applications of extracellular vesicles: clinical promise and open questions

B György, ME Hung, XO Breakefield… - Annual review of …, 2015 - annualreviews.org
This review provides an updated perspective on rapidly proliferating efforts to harness
extracellular vesicles (EVs) for therapeutic applications. We summarize current knowledge …

Extracellular vesicles—connecting kingdoms

E Woith, G Fuhrmann, MF Melzig - International journal of molecular …, 2019 - mdpi.com
It is known that extracellular vesicles (EVs) are shed from cells of almost every type of cell or
organism, showing their ubiquity in all empires of life. EVs are defined as naturally released …

Engineered bacterial membrane vesicles are promising carriers for vaccine design and tumor immunotherapy

Q Long, P Zheng, X Zheng, W Li, L Hua, Z Yang… - Advanced drug delivery …, 2022 - Elsevier
Bacterial membrane vesicles (BMVs) have emerged as novel and promising platforms for
the development of vaccines and immunotherapeutic strategies against infectious and …

A bacterial extracellular vesicle‐based intranasal vaccine against SARS‐CoV‐2 protects against disease and elicits neutralizing antibodies to wild‐type and Delta …

L Jiang, TAP Driedonks, WSP Jong… - Journal of …, 2022 - Wiley Online Library
Several vaccines have been introduced to combat the coronavirus infectious disease‐2019
(COVID‐19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS …