Tumor microenvironment: barrier or opportunity towards effective cancer therapy
Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …
The roles of matrix metalloproteinases and their inhibitors in human diseases
Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM)
remodeling endopeptidases that have the capacity to degrade almost every component of …
remodeling endopeptidases that have the capacity to degrade almost every component of …
Targeting copper in cancer therapy: 'Copper That Cancer'
Copper is an essential micronutrient involved in fundamental life processes that are
conserved throughout all forms of life. The ability of copper to catalyze oxidation–reduction …
conserved throughout all forms of life. The ability of copper to catalyze oxidation–reduction …
TIMPs: versatile extracellular regulators in cancer
HW Jackson, V Defamie, P Waterhouse… - Nature Reviews …, 2017 - nature.com
A compelling long-term goal of cancer biology is to understand the crucial players during
tumorigenesis in order to develop new interventions. Here, we review how the four non …
tumorigenesis in order to develop new interventions. Here, we review how the four non …
Tumor microenvironment components: Allies of cancer progression
PIR Franco, AP Rodrigues, LB de Menezes… - … -Research and Practice, 2020 - Elsevier
Cancer is a disease that affects millions of individuals worldwide and has a great impact on
public health. Therefore, the study of tumor biology and an understanding of how the …
public health. Therefore, the study of tumor biology and an understanding of how the …
Matrix stiffening promotes a tumor vasculature phenotype
F Bordeleau, BN Mason, EM Lollis… - Proceedings of the …, 2017 - National Acad Sciences
Tumor microvasculature tends to be malformed, more permeable, and more tortuous than
vessels in healthy tissue, effects that have been largely attributed to up-regulated VEGF …
vessels in healthy tissue, effects that have been largely attributed to up-regulated VEGF …
The extracellular matrix: a dynamic niche in cancer progression
The local microenvironment, or niche, of a cancer cell plays important roles in cancer
development. A major component of the niche is the extracellular matrix (ECM), a complex …
development. A major component of the niche is the extracellular matrix (ECM), a complex …
[HTML][HTML] Recent developments in myofibroblast biology: paradigms for connective tissue remodeling
The discovery of the myofibroblast has opened new perspectives for the comprehension of
the biological mechanisms involved in wound healing and fibrotic diseases. In recent years …
the biological mechanisms involved in wound healing and fibrotic diseases. In recent years …
The myofibroblast matrix: implications for tissue repair and fibrosis
Myofibroblasts, and the extracellular matrix (ECM) in which they reside, are critical
components of wound healing and fibrosis. The ECM, traditionally viewed as the structural …
components of wound healing and fibrosis. The ECM, traditionally viewed as the structural …
The rationale for targeting the LOX family in cancer
The therapeutic targeting of extracellular proteins is becoming hugely attractive in light of
evidence implicating the tumour microenvironment as pivotal in all aspects of tumour …
evidence implicating the tumour microenvironment as pivotal in all aspects of tumour …