Lung cancer is the second most frequently diagnosed cancer worldwide and a leading
cause of cancer-related deaths. Non-small cell lung carcinoma (NSCLC) represents 85% of …

Cetuximab is approved for the treatment of metastatic colorectal cancer (mCRC) with RAS
wild-type. Nevertheless, the prognosis remains poor and the effectiveness of cetuximab is …

Lung cancer is one of the most common solid tumors worldwide and the leading cause of
cancer-related deaths, causing a devastating impact on human health. The clinical …

Drug combinations are key to circumvent resistance mechanisms compromising response to
single anti-cancer targeted therapies. The implementation of combinatorial approaches …

K-Ras frequently acquires gain-of-function mutations (K-Ras G12D being the most common)
that trigger significant transcriptomic and proteomic changes to drive tumorigenesis …

Background & Aims Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumor
that is almost uniformly lethal in humans. Activating mutations of KRAS are found in> 90% of …

Long noncoding RNAs (lncRNAs) play essential roles in the development and progression
of many cancers. However, the contributions of lncRNAs to medulloblastoma (MB) remain …

Background TP53, the most frequently mutated gene in human cancers, orchestrates a
complex transcriptional program crucial for cancer prevention. While certain TP53 …

Aims Papillary renal neoplasm with reverse polarity (PRNRP) is a newly defined entity with
distinct histomorphology and recurrent KRAS mutation. It has been estimated to constitute …

Background Retinitis pigmentosa (RP) is a genetically heterogeneous group of
degenerative disorders causing progressive vision loss due to photoreceptor death. RP …