Collagen is the oldest and most abundant extracellular matrix protein that has found many
applications in food, cosmetic, pharmaceutical, and biomedical industries. First, an overview …

Advances in biomaterials and the need for patient-specific bone scaffolds require modern
manufacturing approaches in addition to a design strategy. Hybrid materials such as those …

Of all biologic matrices, decellularized extracellular matrix (dECM) has emerged as a
promising tool used either alone or when combined with other biologics in the fields of tissue …

The elucidation of factors that activate the regeneration of the adult mammalian heart is of
major scientific and therapeutic importance. Here we found that epicardial cells contain a …

The choice of biomaterials available for regenerative medicine continues to grow rapidly,
with new materials often claiming advantages over the short-comings of those already in …

The natural microenvironment of tumors is composed of extracellular matrix (ECM), blood
vasculature, and supporting stromal cells. The physical characteristics of ECM as well as the …

Abstract 3D in vitro models have been used in cancer research as a compromise between 2-
dimensional cultures of isolated cancer cells and the manufactured complexity of xenografts …

Modern synthetic biomaterials are being designed to integrate bioactive ligands within
hydrogel scaffolds for cells to respond and assimilate within the matrix. These advanced …

Clinical translation of scaffold-based bone tissue engineering (BTE) therapy still faces many
challenges despite intense investigations and advancement over the years. To address …

Contractile cells can reorganize fibrous extracellular matrices and form dense tracts of fibers
between neighboring cells. These tracts guide the development of tubular tissue structures …