[HTML][HTML] From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways
Pyroptosis, apoptosis and necroptosis are the most genetically well-defined programmed
cell death (PCD) pathways, and they are intricately involved in both homeostasis and …
cell death (PCD) pathways, and they are intricately involved in both homeostasis and …
Predicting the potential human lncRNA–miRNA interactions based on graph convolution network with conditional random field
Long non-coding RNA (lncRNA) and microRNA (miRNA) are two typical types of non-coding
RNAs (ncRNAs), their interaction plays an important regulatory role in many biological …
RNAs (ncRNAs), their interaction plays an important regulatory role in many biological …
The web of death: the expanding complexity of necroptotic signaling
The past decade has seen the emergence of the necroptosis programmed cell death
pathway as an important contributor to the pathophysiology of myriad diseases. The receptor …
pathway as an important contributor to the pathophysiology of myriad diseases. The receptor …
[HTML][HTML] Caspase-1 and Gasdermin D afford the optimal targets with distinct switching strategies in NLRP1b inflammasome-induced cell death
Inflammasomes are essential complexes of innate immune system, which form the first line
of host defense against pathogens. Mounting evidence accumulates that inflammasome …
of host defense against pathogens. Mounting evidence accumulates that inflammasome …
Modeling and analyzing single-cell multimodal data with deep parametric inference
The proliferation of single-cell multimodal sequencing technologies has enabled us to
understand cellular heterogeneity with multiple views, providing novel and actionable …
understand cellular heterogeneity with multiple views, providing novel and actionable …
Specificity and competition of mRNAs dominate droplet pattern in protein phase separation
F Xu, D Miao, W Li, J **, Z Liu, C Shen, J Zhang… - Physical Review …, 2023 - APS
Phase separation is a ubiquitous and emerging mechanism underlying intracellular
organization. Yet how distinct molecular compositions in phase-separated condensates are …
organization. Yet how distinct molecular compositions in phase-separated condensates are …
Quantifying the underlying landscape, entropy production and biological path of the cell fate decision between apoptosis and pyroptosis
Pyroptosis, a recently identified type of cell death, and apoptosis are fundamental and
complex biological processes that underlie a multitude of diseases. However, the crosstalk …
complex biological processes that underlie a multitude of diseases. However, the crosstalk …
A novel and innovative cancer classification framework through a consecutive utilization of hybrid feature selection
Cancer prediction in the early stage is a topic of major interest in medicine since it allows
accurate and efficient actions for successful medical treatments of cancer. Mostly cancer …
accurate and efficient actions for successful medical treatments of cancer. Mostly cancer …
Biphasic amplitude oscillator characterized by distinct dynamics of trough and crest
Biphasic amplitude dynamics (BAD) of oscillation have been observed in many biological
systems. However, the specific topology structure and regulatory mechanisms underlying …
systems. However, the specific topology structure and regulatory mechanisms underlying …
Predicting prognosis in colorectal cancer patients with curative resection using albumin, lymphocyte count and RAS mutations
T Miyata, T Hayama, T Ozawa, K Nozawa, T Misawa… - Scientific Reports, 2024 - nature.com
Colorectal cancer (CRC) poses a significant global health challenge, demanding reliable
prognostic tools to guide treatment decisions. This study introduces a novel prognostic …
prognostic tools to guide treatment decisions. This study introduces a novel prognostic …