Autoantibodies in neurological disease

H Prüss - Nature reviews immunology, 2021 - nature.com
The realization that autoantibodies can contribute to dysfunction of the brain has brought
about a paradigm shift in neurological diseases over the past decade, offering up important …

Acute symptomatic seizures secondary to autoimmune encephalitis and autoimmune‐associated epilepsy: conceptual definitions

C Steriade, J Britton, RC Dale, A Gadoth, SR Irani… - …, 2020 - Wiley Online Library
Seizures are a well‐recognized and often prominent manifestation of autoimmune
encephalitic syndromes. Progress in detection of pathogenic neural autoantibodies has led …

The importance of early immunotherapy in patients with faciobrachial dystonic seizures

J Thompson, M Bi, AG Murchison, M Makuch, CG Bien… - Brain, 2018 - academic.oup.com
Faciobrachial dystonic seizures and limbic encephalitis closely associate with antibodies to
leucine-rich glioma-inactivated 1 (LGI1). Here, we describe 103 consecutive patients with …

Evaluation of seizure treatment in anti-LGI1, anti-NMDAR, and anti-GABABR encephalitis

MAAM de Bruijn, A van Sonderen… - Neurology, 2019 - neurology.org
Objective This nationwide cohort study evaluates seizure responses to immunotherapy and
antiepileptic drugs (AEDs) in patients with anti-leucine-rich glioma-inactivated 1 (LGI1), anti …

Treatment strategies for autoimmune encephalitis

YW Shin, ST Lee, KI Park, KH Jung… - Therapeutic …, 2018 - journals.sagepub.com
Autoimmune encephalitis is one of the most rapidly growing research topics in neurology.
Along with discoveries of novel antibodies associated with the disease, clinical experience …

The value of LGI1, Caspr2 and voltage-gated potassium channel antibodies in encephalitis

A Van Sonderen, M Petit-Pedrol, J Dalmau… - Nature Reviews …, 2017 - nature.com
The discovery, in 2010, of autoantibodies against the extracellular proteins LGI1 and Caspr2
facilitated a change of view regarding the clinical importance of voltage-gated potassium …

[HTML][HTML] Hippocampal volume across age: Nomograms derived from over 19,700 people in UK Biobank

L Nobis, SG Manohar, SM Smith, F Alfaro-Almagro… - NeuroImage: Clinical, 2019 - Elsevier
Measurement of hippocampal volume has proven useful to diagnose and track progression
in several brain disorders, most notably in Alzheimer's disease (AD). For example, an …

LGI1 antibody encephalitis: acute treatment comparisons and outcome

A Rodriguez, CJ Klein, E Sechi, E Alden… - Journal of Neurology …, 2022 - jnnp.bmj.com
Objective To compare acute treatment responses and long-term outcome in leucine-rich
glioma-inactivated 1 (LGI1) antibody encephalitis. Methods Retrospective case series of 118 …

Prognosticating autoimmune encephalitis: a systematic review

J Broadley, U Seneviratne, P Beech, K Buzzard… - Journal of …, 2019 - Elsevier
Objective To perform a systematic review of the current scientific literature in order to identify
variables associated with patient prognosis in autoimmune encephalitis. Methods We …

LGI1, CASPR2 and related antibodies: a molecular evolution of the phenotypes

SNM Binks, CJ Klein, P Waters, SJ Pittock… - Journal of Neurology …, 2018 - jnnp.bmj.com
Recent biochemical observations have helped redefine antigenic components within the
voltage-gated potassium channel (VGKC) complex. The related autoantibodies may be now …