Extracellular vesicles as biomarkers and therapeutic targets for cancer

F Urabe, N Kosaka, K Ito, T Kimura… - … of Physiology-Cell …, 2019 - journals.physiology.org
Extracellular vesicles (EVs) are small lipid membrane vesicles that are secreted from almost
all kinds of cells into the extracellular space. EVs are widely accepted to be involved in …

Oxidative stress in drug-induced liver injury (DILI): from mechanisms to biomarkers for use in clinical practice

M Villanueva-Paz, L Morán, N López-Alcántara… - Antioxidants, 2021 - mdpi.com
Idiosyncratic drug-induced liver injury (DILI) is a type of hepatic injury caused by an
uncommon drug adverse reaction that can develop to conditions spanning from …

Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood

L Cheng, RA Sharples, BJ Scicluna… - Journal of extracellular …, 2014 - Taylor & Francis
Introduction microRNA (miRNA) are small non-coding RNA species that are transcriptionally
processed in the host cell and released extracellularly into the bloodstream. Normally …

Circulating exosomal microRNAs as biomarkers of colon cancer

H Ogata-Kawata, M Izumiya, D Kurioka, Y Honma… - PloS one, 2014 - journals.plos.org
Purpose Exosomal microRNAs (miRNAs) have been attracting major interest as potential
diagnostic biomarkers of cancer. The aim of this study was to characterize the miRNA …

Evaluation of tumor-derived exosomal miRNA as potential diagnostic biomarkers for early-stage non–small cell lung cancer using next-generation sequencing

X **, Y Chen, H Chen, S Fei, D Chen, X Cai… - Clinical cancer …, 2017 - aacrjournals.org
Purpose: To identify tumor-derived exosomal biomarkers that are able to discriminate
between adenocarcinoma and squamous cell carcinoma (SCC) as a noninvasive method in …

Non-exosomal and exosomal circulatory microRNAs: which are more valid as biomarkers?

NNSB Nik Mohamed Kamal… - Frontiers in …, 2020 - frontiersin.org
MicroRNAs (miRNAs) are a group of small non-coding RNAs with approximately 19–25
nucleotides that are involved in regulating a range of developmental and physiological …

An elevated expression of serum exosomal microRNA-191,− 21,− 451a of pancreatic neoplasm is considered to be efficient diagnostic marker

T Goto, M Fujiya, H Konishi, J Sasajima, S Fujibayashi… - BMC cancer, 2018 - Springer
Background Pancreatic cancer is associated with an extremely poor prognosis, so new
biomarkers that can detect the initial stages are urgently needed. The significance of serum …

Circulating microRNAs as potential biomarkers of infectious disease

CN Correia, NC Nalpas, KE McLoughlin… - Frontiers in …, 2017 - frontiersin.org
microRNAs (miRNAs) are a class of small non-coding endogenous RNA molecules that
regulate a wide range of biological processes by post-transcriptionally regulating gene …

Normalization of circulating microRNA expression data obtained by quantitative real-time RT-PCR

F Marabita, P De Candia, A Torri… - Briefings in …, 2016 - academic.oup.com
The high-throughput analysis of microRNAs (miRNAs) circulating within the blood of healthy
and diseased individuals is an active area of biomarker research. Whereas quantitative real …

[HTML][HTML] Impact of storage conditions on EV integrity/surface markers and cargos

A Sivanantham, Y ** - Life, 2022 - mdpi.com
Extracellular vesicles (EVs) are small biological particles released into biofluids by every
cell. Based on their size, they are classified into small EVs (< 100 nm or< 200 nm) and …