Background Several reports suggest that implementation of the Surviving Sepsis Campaign
(SSC) guidelines is associated with mortality reduction in sepsis. However, adherence to the …

Prior to 2001 there was no standard for early management of severe sepsis and septic
shock in the emergency department. In the presence of standard or usual care, the …

Purpose Guidelines recommend administering antibiotics within 1 h of sepsis recognition
but this recommendation remains untested by randomized trials. This trial was set up to …

Rationale: Severe sepsis and septic shock are leading causes of intensive care unit (ICU)
admission, morbidity, and mortality. The effect of compliance with sepsis management …

Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease
involving loss of motor neurons and having no known cure and uncertain etiology. Several …

Background Procalcitonin (PCT)-protocols to guide antibiotic treatment in severe infections
are known to be effective. But less is known about the long-term effects of such protocols on …

Background Previous studies showed higher sepsis mortality rates in Brazil compared to
other developed or develo** countries. Moreover, another trial demonstrated an …

Objective: To compare the clinical characteristics and outcomes of patients with community-
acquired and hospitalacquired sepsis. Methods: This is a retrospective cohort study that …

Background There is ample literature available on the association between both time to
antibiotics and appropriateness of antibiotics and clinical outcomes from sepsis. In fact, the …

Sepsis and septic shock are the major causes of death in intensive care units. Oxidative
damage to mitochondria is involved in the development of organ dysfunction associated with …