Alterations of the gut microbiota may cause dysregulated mucosal immune responses
leading to the onset of inflammatory bowel diseases (IBD) in genetically susceptible hosts …

Receptors of the innate immune system detect conserved determinants of microbial and viral
origin. Activation of these receptors initiates signaling events that culminate in an effective …

Recent advances have provided substantial insight into the maintenance of mucosal
immunity and the pathogenesis of inflammatory bowel disease. Cellular programs …

Immunity to pathogens critically requires pattern-recognition receptors (PRRs) to trigger
intracellular signaling cascades that initiate and direct innate and adaptive immune …

Production of the proinflammatory cytokine interleukin 1β (IL-1β) by dendritic cells is crucial
in host defense. Here we identify a previously unknown role for dectin-1 in the activation of a …

Pathogen recognition by C-type lectin receptors (CLRs) expressed by dendritic cells is
important not only for antigen presentation, but also for the induction of appropriate adaptive …

Myeloid cells are key drivers of physiological responses to pathogen invasion or tissue
damage. Members of the C-type lectin receptor (CLR) family stand out among the …

Metabolic diseases, such as type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver
disease (NAFLD) and obesity, have become a major public health problem worldwide. In …

Humoral autoimmunity paralleled by the accumulation of follicular helper T cells (TFH cells)
is linked to mutation of the gene encoding the RNA-binding protein roquin-1. Here we found …

The skin is an organ harboring several types of immune cells that participate in innate and
adaptive immune responses. The immune system of the skin comprises both skin cells and …